The diagnostic of cancer during pregnancy is a rare and delicate situation. As the developments of the embryo and the human fetus are extremely sensitive to ionizing radiations, the treatment of these tumors should be discussed. The studies - preclinical and clinical - based mostly on exposure accidents show that subdiaphragmatic treatments are possible during pregnancy. When radiotherapy is used, phantom estimations of the dose to the fetus, confirmed by in vivo measurements are required. Irradiation and imaging techniques should be arranged to decrease as much as possible the dose delivered to the fetus and hold below the threshold of 0.1Gy.
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http://dx.doi.org/10.1016/j.canrad.2016.07.024 | DOI Listing |
Curr Neuropharmacol
December 2024
IRCCS Neuromed, 86077 Pozzilli (IS), Italy.
Background: The study demonstrates that pharmacological blockade of type 3 metabotropic glutamate (mGlu3) receptors at the time of tumor induction significantly reduces the incidence of brain gliomas in rats. The overall survival of patients with high-grade brain gliomas is 14-20 months after current multimodal therapy, including surgery, radiotherapy, and adjuvant chemotherapy.
Objective: To demonstrate in this experimental model that pharmacological blockade of group II metabotropic glutamate receptors reduces the incidence of brain tumors induced by prenatal exposure to N- ethyl-N-nitrosourea (ENU) in rats.
Acta Obstet Gynecol Scand
November 2024
Department of Reproductive Medicine, Division of Gynecology and Reproduction, Karolinska University Hospital, Stockholm, Sweden.
Arch Endocrinol Metab
November 2024
Instituto Nacional de Câncer Departamento de Endocrinologia Oncológica Rio de JaneiroRJ Brasil Departamento de Endocrinologia Oncológica, Instituto Nacional de Câncer (Inca), Rio de Janeiro, RJ, Brasil.
Objective: Patients with pediatric differentiated thyroid carcinoma (DTC) treated with radioiodine (RAI) therapy may experience long-term side effects, such as gonadal dysfunction. Therefore, it is crucial to understand the impact of this therapy on ovarian reserve and future pregnancy rates.
Subjects And Methods: Retrospective analysis of 64 female DTC survivors of childbearing age to assess the risk of infertility due to RAI performed before the age of 19 years.
Physiol Res
November 2024
The Fourth Department of Internal Medicine - Hematology, University Hospital Hradec Králové and Charles University, Faculty of Medicine in Hradec Králové, Hradec Králové, Czech Republic.
Lasers Med Sci
November 2024
Nazan Yilmaz Dermatology Clinic, Istanbul, Turkey.
Striae distensae (SD) are a prevalent dermatological concern of women and approximately 90% of pregnant women experience these stretch marks. Fractional microneedle radiofrequency (FMR) and fractional CO2 laser (FCL) have gained substantial attention in the treatment of SD. In clinical studies, a clear superiority between FMR and FCL treatments is not found due to limited studies and sample sizes.
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