AI Article Synopsis
- The study aimed to understand the delay between transdermal alcohol concentration (TAC) and breath alcohol concentration (BrAC), finding that TAC reacts slower but provides a less invasive measurement of alcohol consumption.
- Results showed that as participants consumed more beers, both the peak TAC and peak BrAC values rose, but the peak TAC was consistently lower and took longer to reach compared to BrAC.
- While women generally experienced longer times to reach peak alcohol levels than men, the congruence of TAC and BrAC improved with increased beer consumption, with no significant differences in time lag based on sex.
Article Abstract
Aims: Monitors of transdermal alcohol concentration (TAC) provide an objective measurement of alcohol consumption that is less invasive than measurements in blood, breath or urine; however, there is a substantial time delay in the onset of TAC compared to blood or breath alcohol concentrations (BrACs). The current study examined the characteristics of the delay between peak TAC and peak BrAC.
Methods: Data was aggregated from three experimental laboratory studies (N = 61; 32 men, 29 women) in which participants wore a TAC monitor and BrAC was monitored while drinking one, two, three, four and five beers in the laboratory. Analyses examined the sex- and dose-related differences in peak BrAC and TAC, the time-to-peak BrAC and TAC, and time lag between the peak BrAC and TAC values.
Results: The times-to-peak were an increasing function of the number of beers consumed. At each level of beer consumption the peak TAC averaged lower than peak BrAC and times-to-peak TAC were longer than for BrAC. The time-to-peak BrAC and TAC was longer for women than men. The congruence between peak TAC and BrAC increased as a function of the beers consumed. No sex difference in the time lag between peak BrAC and TAC was detected.
Conclusions: The congruence between TAC and BrAC and time lags between TAC and BrAC are related to the number of beers consumed. Peak values of TAC and BrAC became more congruent with higher doses but the time lag increased as a function of the amount of alcohol consumed.
Short Summary: The time delay (or lag) and congruence between transdermal vs. BrACs increases as the number of beers increases. Though sex differences are evident in peak transdermal and BrACs, no sex differences were evident in the time lag and the congruence between transdermal and breath alcohol concentrations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5169032 | PMC |
| http://dx.doi.org/10.1093/alcalc/agw058 | DOI Listing |
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