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Nanodrug-Engineered Exosomes Achieve a Jointly Dual-Pathway Inhibition on Cuproptosis.
Adv Sci (Weinh)
December 2024
The Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, 310000, China.
Cuproptosis, caused by an intracellular overload of copper (Cu) ions and overexpression of ferredoxin 1 (FDX1), is identified for its regulatory role in the skin wound healing process. This study verifies the presence of cuproptosis in skin wound beds and reactive oxygen species-induced cells model. To address the two pathways leading to cell cuproptosis, a nanodrug-engineered exosomes is proposed.
View Article and Find Full Text PDFα-Lipoic acid: a potential regulator of copper metabolism in Alzheimer's disease.
Front Mol Biosci
September 2024
Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.
Alzheimer's disease (AD) is characterized by classic hallmarks such as amyloid plaques and neurofibrillary tangles, however, intensive research has broadened its scope to explore additional underlying mechanisms. Notably, disruptions in metal homeostasis, particularly involving copper, have gained significant attention. In AD pathology, an imbalance is evident: there is an excess of extracellular copper alongside a deficiency in intracellular copper in brain tissue.
View Article and Find Full Text PDF[Toward the complete understanding of the pathogenic mechanism of clioquinol-induced subacute myelo-optic neuropathy (SMON)].
Nihon Yakurigaku Zasshi
March 2024
Radioisotope Center, Kyoto Prefectural University of Medicine.
Clioquinol was extensively used as an amebicide to treat indigestion and diarrhea in the mid-1900s. However, it was withdrawn from the market in Japan because its use was epidemiologically linked to an increase in the incidence of subacute myelo-optic neuropathy (SMON). SMON is characterized by the subacute onset of sensory and motor disturbances in the lower extremities with occasional visual impairments, which are preceded by abdominal symptoms.
View Article and Find Full Text PDFThe 8-hydroxyquinoline derivative, clioquinol, is an alpha-1 adrenoceptor antagonist.
Biochem Pharmacol
April 2024
Translational Neurodegeneration Laboratory, Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Victoria, Australia. Electronic address:
Clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) is an antimicrobial agent whose actions as a zinc or copper ionophore and an iron chelator revived the interest in similar compounds for the treatment of fungal and bacterial infections, neurodegeneration and cancer. Recently, we reported zinc ionophores, including clioquinol, cause vasorelaxation in isolated arteries through mechanisms that involve sensory nerves, endothelium and vascular smooth muscle. Here, we report that clioquinol also uniquely acts as a competitive alpha-1 (α) adrenoceptor antagonist.
View Article and Find Full Text PDFUnderstanding Alzheimer's Disease and its Metal Chelation Therapeutics: A Narrative Review.
Curr Pharm Des
November 2023
Central Council for Research in Unani Medicine (CCRUM), Ministry of Ayush, Government of India, Janakpuri, New Delhi 110058, India.
The neurodegenerative disorders are age-related illnesses that cause the morphology or activity of neurons to deteriorate over time. Alzheimer's disease is the most frequent neurodegenerative illness in the long run. The rate of advancement might vary, even though it is a progressive neurological illness.
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