AI Article Synopsis
- The study aimed to assess changes in the apparent diffusion coefficient (ADC) histogram in breast cancer patients undergoing neoadjuvant chemotherapy (NAC) and to compare these changes between responders and non-responders.
- A total of 62 patients were evaluated using 3T magnetic resonance imaging before and after two cycles of NAC, with responders defined as those showing at least a 30% reduction in tumor cells.
- Results indicated significant increases in various ADC percentiles for all patients after NAC, with responders showing a tendency for greater increases compared to non-responders, highlighting the potential of ADC histogram analysis as a quantitative tool during treatment.
Article Abstract
Purpose: To evaluate the changes in the apparent diffusion coefficient (ADC) histogram during neoadjuvant chemotherapy (NAC) for breast cancer, and to compare the observed changes in pathologically verified responders and non-responders.
Materials And Methods: Sixty-two patients received NAC followed by surgery. Responders were defined by a tumor cell reduction of at least 30 % using the Miller-Payne grading system. All the patients underwent 3T magnetic resonance with diffusion-weighted imaging (b values of 0 and 750 s/mm) before the NAC and after the completion of two cycles of NAC.
Results: Mean, minimum, 10th, 25th, 50th, and 75th percentile of ADCs significantly increased after NAC and maximum ADC significantly decreased. Skewness became less positive and kurtosis decreased. A tendential, although not statistically significant, higher increase in mean, minimum, 10th, 25th, 50th, 75th, and 90th percentiles of ADCs was observed in responders in comparison with non-responders.
Conclusion: ADC histogram analysis quantitatively demonstrates the alterations during the treatment course.
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| http://dx.doi.org/10.1007/s11604-016-0570-2 | DOI Listing |
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