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extracellular replication of endobacteria.
Front Microbiol
July 2024
Institute for Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany.
Obligate intracellular endobacteria of the genus are widespread in arthropods and several filarial nematodes. Control programs for vector-borne diseases (dengue, Zika, malaria) and anti-filarial therapy with antibiotics are based on this important endosymbiont. Investigating , however, is impeded by the need for host cells.
View Article and Find Full Text PDFDirofilariasis mouse models for heartworm preclinical research.
Front Microbiol
June 2023
Department of Tropical Disease Biology, Centre for Drugs and Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom.
Introduction: Dirofilariasis, including heartworm disease, is a major emergent veterinary parasitic infection and a human zoonosis. Currently, experimental infections of cats and dogs are used in veterinary heartworm preclinical drug research.
Methods: As a refined alternative heartworm preventative drug screen, we assessed lymphopenic mouse strains with ablation of the interleukin-2/7 common gamma chain (γc) as susceptible to the larval development phase of .
Histopathological evaluation of nodules by microscopy and by digital image analysis for the study of macrofilaricidal drug efficacy.
Front Med (Lausanne)
February 2023
Institute for Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn, Bonn, Germany.
Background: Novel drugs or drug combinations that kill or permanently sterilize adult worms would be very helpful for treatment and elimination of onchocerciasis. In absence of a reliable biomarker for viable adult worms, histopathological assessment of worms within onchocercal nodules is a standard method to determine macrofilaricidal activity. The goal of the present study was to determine the agreement between two independent experts in the analysis of nodule sections and to assess the value of digital imaging as a means of standardizing the analysis.
View Article and Find Full Text PDFDetection of Wolbachia in Mosquitoes (Diptera: Culicidae) in the State of Maranhão, Brazil.
J Med Entomol
September 2022
Laboratório de Entomologia e Vetores, Universidade Federal do Maranhão, Avenida dos Portugueses 1966, Campus do Bacanga, 65080-805, São Luís, Maranhão, Brazil.
Article Synopsis
- Researchers studied the presence of the endobacteria Wolbachia in mosquito species from Maranhão, Brazil, as a potential method for controlling arboviruses.
- They analyzed a total of 448 mosquito specimens from six locations, discovering Wolbachia DNA in seven species, three of which are newly identified in this context.
- The overall infection rate of Wolbachia among the mosquito species varied from 0% to 80%, with an average rate of 16.5%, enhancing our understanding of its prevalence for future biological control strategies.
Corallopyronin A: antimicrobial discovery to preclinical development.
Nat Prod Rep
September 2022
German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Germany.
Covering: August 1984 up to January 2022Worldwide, increasing morbidity and mortality due to antibiotic-resistant microbial infections has been observed. Therefore, better prevention and control of infectious diseases, as well as appropriate use of approved antibacterial drugs are crucial. There is also an urgent need for the continuous development and supply of novel antibiotics.
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