Comparison of the Impact of 68Ga-DOTATATE and 18F-FDG PET/CT on Clinical Management in Patients with Neuroendocrine Tumors.

Unlabelled: This study aimed to assess the clinical impact of Ga-DOTATATE and F-FDG with respect to the management plan and to evaluate the prognostic value of both tracers.

Methods: A total of 104 patients (55 male and 49 female; median age, 58 y; range, 20-90 y) with histologically proven neuroendocrine tumors (NETs) underwent both Ga-DOTATATE and F-FDG PET/CT. Twenty-eight patients (26.9%) had poorly differentiated tumors, and 76 (73.1%) had well-differentiated tumors. PET/CT results and SUVs were compared with prognostic factors such as histologic grade (G1, G2, or G3, for low-grade [well differentiated], intermediate-grade [moderately differentiated], and high-grade [poorly differentiated], respectively), chromogranin A, and proliferation index (Ki-67).

Results: The Ga-DOTATATE and F-FDG PET/CT findings were discordant in 65 patients (62.5%) and concordant in 39 patients (37.5%). The results changed the therapeutic plan in 84 patients (80.8%). In 22 patients (21.1%), decision making was based on the F-FDG findings; in 32 (30.8%), on the findings with both radiotracers; and in 50 (48.1%), on the Ga-DOTATATE findings. The most frequent management decision based on F-FDG was initiation of chemotherapy (10 patients, 47.6%). The most common treatment decision due to Ga-DOTATATE was initiation of peptide receptor radionuclide therapy (14 patients, 27.4%). In 11 (39.2%) of 28 patients with poorly differentiated NETs, the management decision was based on only the F-FDG results. For Ga-DOTATATE, SUV was higher for G1 tumors and lower for G3 tumors (P = 0.012). However, no significant differences in F-FDG-derived SUVs were observed between different grades (P = 0.38). The Mann-Whitney test showed significant differences in Ga-DOTATATE SUV between tumors with a Ki-67 of less than 5% and tumors with a Ki-67 of more than 5% (P = 0.004), without significance differences in F-FDG SUV Log-rank analysis showed statistically significant differences in survival for patients with bone metastasis versus soft-tissue or no metastasis for both F-FDG (P = 0.037) and Ga-DOTATATE (P = 0.047). Overall survival declined rapidly with increasing grade (P = 0.001), at an estimated 91 mo for G1, 59 mo for G2, and 48 mo for G3.

Conclusion: F-FDG PET/CT had no clinical impact on G1 NETs and a moderate impact on G2 NETs. However, in poorly differentiated NETs, F-FDG PET/CT plays a significant clinical role in combination with Ga-DOTATATE. Ga DOTATATE SUV relates to grade and Ki-67 and can be used prognostically.