Background: Bariatric surgery has been proven to be a safe and effective treatment for obesity with BMI (body mass index) reduction, and resolution or lowering of obesity-related co-morbidities. The relative age limit for bariatric surgery has gradually been increased to 60 years of age and above.
Objectives: The aim of this study was to assess the safety and efficacy of laparoscopic sleeve gastrectomy (LSG) performed in older patients (≥65 years old).
Setting: University hospital.
Methods: Between May 1, 2007 and November 30, 2013, 30 consecutive patients≥65 years old were included in this retrospective study of our prospectively collected bariatric database.
Results: A total of 27 (90%) primary LSG and 3 revisional LSG (10%) were performed. Mean patient age was 67.2 (range: 65-74) years, and mean preoperative BMI (±standard deviation [SD]) was 44.1±5.6 kg/m. Thirty-day morbidity included 3 cases of self-limiting nausea and vomiting and 1 case of gastric sleeve stenosis necessitating conversion to gastric bypass. No mortality reported. The overall mean percentage of excess weight loss (±SD) and percentage of total weight loss (±SD) at 12 months were 53.8±19.8 and 23.9±8.4; 52.9±21.8 and 24±9.9 at 36 months, respectively. No patients were lost to follow-up but 5 were excluded because they underwent revisions. Age-adjusted mixed model analyses revealed that baseline BMI (P = .018), BMI>45 kg/m (P = .001), and having diabetes (P = .030) were associated with excess weight loss<50% across follow-up.
Conclusion: LSG seems to be effective and safe for patients≥65 years old. Obesity related co-morbidities have improved across follow-up. BMI>45 kg/m and diabetes is associated with insufficient weight loss or weight regain.
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http://dx.doi.org/10.1016/j.soard.2016.05.020 | DOI Listing |
J Med Internet Res
March 2025
Department of Pharmacology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Background: Acceptance and commitment therapy provides a psychobehavioral framework feasible for digital and hybrid weight loss interventions. In face-to-face studies, group-based interventions yield more favorable outcomes than individual interventions, but the effect of the intervention form has not been studied in combination with eHealth.
Objective: This study investigated whether a minimal, 3-session group or individual enhancement could provide additional benefits compared to an eHealth-only intervention when assessing weight, body composition, and laboratory metrics in a sample of occupational health patients with obesity.
Anesthesiology
March 2025
Professor of Anesthesiology and Perioperative Medicine, Department of Basic and Applied Medical Sciences, Ghent University, Ghent, Belgium; Professor, Department of Anesthesiology, UZLeuven, Leuven, Belgium & Department of Cardiovascular Sciences, KULeuven, Leuven, Belgium; Staff anesthesiologist, Department of Anesthesiology, OLV Hospital, Aalst, Belgium.
Background: The use of capturing devices may become required for the continued use desflurane. We tested the percentage of desflurane captured by a charcoal filter (CONTRAfluran)-workstation (Aisys) combination in vitro.
Methods: Desflurane in O2/air was administered via an Aisys workstation into a 2 L test lung that was insufflated with CO2 (160 mL/min).
J Immunol
January 2025
Center for Inflammation, Immunity and Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, GA, United States.
Current influenza vaccines are not effective in conferring protection against antigenic variants and pandemics. To improve cross-protection of influenza vaccination, we developed a 5xM2e messenger RNA (mRNA) vaccine encoding the tandem repeat conserved ectodomain (M2e) of ion channel protein M2 derived from human, swine, and avian influenza A viruses. The lipid nanoparticle (LNP)-encapsulated 5xM2e mRNA vaccine was immunogenic, eliciting high levels of M2e-specific IgG antibodies, IFN-γ+ T cells, T follicular helper cells, germinal center phenotypic B cells, and plasma cells.
View Article and Find Full Text PDFAm J Physiol Endocrinol Metab
March 2025
MaineHeath Institute for Research, Center for Molecular Medicine, Scarborough, Maine, United States.
Obesity is a global health challenge associated with significant metabolic and cardiovascular risks. Bariatric surgery and GLP-1 receptor agonists (GLP-1RAs) are effective interventions for weight loss and metabolic improvement, yet their comparative effects on systemic metabolism-particularly energy metabolism, bone health, and heart function-remain unclear. In this study, obese male mice underwent vertical sleeve gastrectomy (VSG), 6 weeks of GLP-1RA (semaglutide) treatment, or sham procedure with saline injection as controls.
View Article and Find Full Text PDFJ Nephrol
March 2025
Nephrology Dialysis and Kidney Transplant Unit, Azienda Ospedaliero Universitaria di Modena, Via del pozzo 71, 41122, Modena, Italy.
The adsorption technique has opened a new frontier in the field of purification through hemodialysis. This technique has proved to be effective in removing uremic toxins previously deemed inaccessible due to their size or charge, as well as to their molecular interactions with blood proteins. In this context, this review provides a detailed explanation of the role of Polyester-polymer alloy (PEPA®) membranes and hemodiafiltration with endogenous reinfusion.
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