AI Article Synopsis
- The study focused on creating MCM-41 mesoporous silica nanoparticles (NPs) and their modified version with iron (MCM-41÷Fe3O4) to be used as drug delivery systems for various bioactive agents.
- The nanoparticles were characterized using advanced techniques such as TEM, SEM, and XRD, while drug release was analyzed using a modified HPLC method.
- It was found that the release of folic acid from these structures is sensitive to pH levels, with lower delivery in strongly acidic conditions, which could help protect folic acid from degradation in the stomach.
Article Abstract
In this study, MCM-41 mesoporous silica nanoparticles (NPs) and MCM-41÷Fe3O4 mesoporous silica NPs were prepared by sol-gel method using CTAB (cetyltrimethylammonium bromide) as template and TEOS (tetraethyl orthosilicate) as silica precursor in order to use these materials as drug delivery system (DDS) for different biologically active agents. The MCM-41 and MCM-41÷Fe3O4 mesoporous silica NPs were characterized using specific physico-chemical methods [transmission electron microscopy (TEM), scanning electron microscopy (SEM), nitrogen adsorption and desorption studies - BET (Brunauer-Emmett-Teller) method, X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy], while the release studies were done by a high-performance liquid chromatography (HPLC)-modified method. The pH dependence of the delivery of folic acid from the mesoporous structures was analyzed and found that the release is pH sensitive. The lower delivery at strongly acid pH comparing with neutral/slightly alkaline pH could be beneficial because in stomach the folic acid can be destroyed.
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