AI Article Synopsis
- The study investigates the HLA Class I and II genotype profiles in hepatitis C virus (HCV) infected patients from Northern India.
- The research analyzed 148 anti-HCV-positive patients over a period from January 2013 to August 2014 and found significant changes in specific HLA allele frequencies compared to control groups.
- Notably, certain HLA alleles showed geographic variation in frequencies among HCV-infected individuals in India, highlighting the potential role of genetic factors in HCV susceptibility.
Article Abstract
Purpose: Humans are the only known natural hosts of hepatitis C virus (HCV). This study was undertaken to examine the frequencies of human leucocyte antigens (HLAs) Class I and Class II genotype profiles in anti-HCV-infected patients of Northern India.
Materials And Methods: From a period of January 2013 to August 2014, 148 anti-HCV-positive patients of North India referred to the Department of Molecular Biology and Transplant Immunology, Indraprastha Apollo Hospitals, New Delhi, for performing HLA typing were included in the study.
Results: AFNx0102, AFNx0131 allele frequency decreased significantly in anti-HCV-positive patients. Frequencies for HLA-B loci did not reach any statistical significance. Among the Class II alleles, HLA-DRB1FNx0103 and HLA-DRB1FNx0110 were significantly higher in the patient population, and HLA-DRB1FNx0115 was significantly decreased in the patient population as compared to the controls.
Conclusion: HLA-AFNx0133 was significantly increased as compared to control population and showed geographic variation in HCV-infected individuals of India.
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| http://dx.doi.org/10.4103/0255-0857.188317 | DOI Listing |
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