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Objective: Early detection of ovarian cancer can improve patient outcomes; however, screening tests can yield false-positive results, leading to unnecessary surgical interventions. This systematic review explores the prevalence of false-positive ovarian cancer screenings and subsequent unnecessary surgical interventions.
Methods And Analysis: Five databases were searched in March 2023 and again in March 2024, encompassing primary literature published between 2003 and 2024.
Impact of using time-averaged exposure metrics on binary endpoints in exposure-response analyses.
Front Pharmacol
January 2025
Certara Inc., Melbourne, VIC, Australia.
Exposure-response (ER) analyses are routinely performed as part of model-informed drug development to evaluate the risk-to-benefit ratio for dose selection, justification, and confirmation. For logistic regression analyses with binary endpoints, several exposure metrics are investigated, based on pharmacological plausibility, including time-averaged concentration to event (C). C is informative because it accounts for dose interruptions, modifications, and reductions and is therefore often compared against ER relationships identified using steady-state exposures.
View Article and Find Full Text PDFDiagnostic Performance of the Modified Lung-RADS in a Tuberculosis-endemic Country: The Korean National Lung Cancer Screening Program.
Chest
January 2025
Division of Cancer Early Detection, National Cancer Control Institute, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang 10408, Korea. Electronic address:
Background: In 2019, Korea initiated the world's first national low-dose computed tomography (CT) lung cancer screening (LCS) program, adapting the Lung CT Screening Reporting and Data System (Lung-RADS) to counteract the high false-positive rates driven by prevalent tuberculosis.
Research Question: Does the modified Lung-RADS enhance screening specificity while maintaining sensitivity?
Study Design And Methods: This nationwide, retrospective, cohort study included high-risk current smokers aged 54 to 74 with at least 30 pack-years, participating in the national LCS program from 2019 to 2020. The modified Lung-RADS 1.
Case report: Vulvar metastasis after lung metastasis in cervical squamous cell carcinoma, a case report and literature review.
Int J Surg Case Rep
January 2025
Department of Obstetrics and Gynecology, West China Second University Hospital of Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. Electronic address:
Introduction And Importance: Cervical cancer is highly correlated with high-risk human papillomavirus (HPV) infection, accounting for approximately 70 % of cases. However, false-negative HPV test results can occur, complicating early detection.
Case Presentation: We introduce a rare case of cervical cancer with lung metastasis followed by vulvar metastasis.
Identifying metabolomic mediators of the physical activity and colorectal cancer relationship.
Cancer Epidemiol Biomarkers Prev
January 2025
University of Bristol, Bristol, United Kingdom.
Background: Current evidence suggests higher physical activity (PA) levels are associated with a reduced risk of colorectal cancer (CRC). However, the mediating role of the circulating metabolome in this relationship remains unclear.
Methods: Targeted metabolomics data from 6,055 participants in the EPIC cohort were used to identify metabolites associated with PA and derive a metabolomic signature of PA levels.
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