We report a case of drug-induced myoclonus possibly related to palonosetron, a second-generation 5-hydroxytryptamine-3 receptor antagonist which was administered as a prophylaxis for postoperative nausea and vomiting in a 28-year-old female. The recurrent episodes of myoclonus jerk involving the head, neck and shoulder persisted for a period of 4 days. The patient also exhibited an episode of severe bradycardia leading to hypotension 7 h after surgery. To our knowledge, this is the first report presenting these adverse events potentially associated with the use of palonosetron.
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Article Synopsis
- - Asterixis is a type of negative myoclonus that involves brief, irregular pauses in muscle contraction, leading to lapses in maintaining posture and is often associated with conditions like hepatic encephalopathy and renal failure.
- - It is essential to differentiate asterixis from other forms of negative myoclonus, such as epileptic negative myoclonus, as this can affect treatment approaches.
- - Asterixis typically shows no symptoms during patient self-reporting and can often be easily overlooked; however, it is usually reversible with appropriate treatment of the underlying medical issue.
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