AI Article Synopsis
- The paper discusses creating a curcumin cross-linked collagen aerogel that shows controlled anti-proteolytic activity and promotes blood vessel formation (pro-angiogenesis).
- The study confirmed that the cross-linking process maintained the structural integrity of collagen, resulting in aerogels with improved physical and mechanical properties, along with strong anti-microbial effects.
- These 3D aerogels provide an optimal environment for cell growth, making them promising candidates for use in biomedical applications as biocompatible and bioresorbable scaffolds.
Article Abstract
This paper elucidates the development of a curcumin cross-linked collagen aerogel system with controlled anti-proteolytic activity and pro-angiogenic efficacy. The results of this study showed that in situ cross-linking of curcumin with collagen leads to the development of aerogels with enhanced physical and mechanical properties. The integrity of collagen after cross-linking with curcumin was studied via FTIR spectroscopy. The results confirmed that the cross-linking with curcumin did not induce any structural changes in the collagen. The curcumin cross-linked collagen aerogels exhibited potent anti-proteolytic and anti-microbial activity. Scanning electron and atomic force microscopic analysis of curcumin cross-linked collagen aerogels showed a 3D microstructure that enhanced the adhesion and proliferation of cells. The highly organized geometry of collagen-curcumin aerogels enhanced the permeability and water-retaining ability required for the diffusion of nutrients that aid cellular growth. The pro-angiogenic properties of collagen-curcumin aerogels were ascribed to the cumulative effect of the nutraceutical and the collagen molecule, which augmented the restoration of damaged tissue. Further, these aerogels exhibited controlled anti-proteolytic activity, which makes them suitable 3D scaffolds for biomedical applications. This study provides scope for the development of biocompatible and bioresorbable collagen aerogel systems that use a nutraceutical as a cross-linker for biomedical applications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1088/1748-6041/11/4/045011 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Chitosan/squid ring teeth protein hydrogels for the controlled release of curcumin.
Int J Biol Macromol
December 2024
Key Laboratory of Health Risk Factors for Seafood of Zhejiang Province, Zhejiang Ocean University, Zhoushan 316022, China; College of Food and Medicine, Zhejiang Ocean University, Zhoushan 316022, China. Electronic address:
Biocompatible and degradable hydrogels are extensively utilized for the delivery and controlled release of bioactive agents. Chitosan/squid ring teeth protein (SRT) hydrogels (CH/SRTs) cross-linked by genipin were fabricated, and their gel properties and structural characteristics were analyzed across varying SRT contents. Additionally, the curcumin-release behavior of curcumin-loaded CH/SRTs (Cur-CH/SRTs) was evaluated.
View Article and Find Full Text PDFEnhanced Bioaccessibility and Antioxidant Activity of Curcumin from Transglutaminase Cross-Linked Mulberry Leaf Protein-Stabilized High-Internal-Phase Pickering Emulsion: In Vivo and In Vitro Studies.
Foods
December 2024
State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang 330047, China.
The objective of this study was to formulate Pickering emulsions stabilized by transglutaminase cross-linked mulberry leaf protein (TG-MLP) nanoparticles as a delivery system for curcumin (Cur) and to assess its bioaccessibility both in vivo and in vitro. The encapsulation efficiency of curcumin in high-internal-phase Pickering emulsions (HIPEs) prepared at pH 10 with a 20 mg/mL concentration of TG-MLP reached 93%. Compared to Oil-Cur, Cur-HIPEs exhibited superior antioxidant activity.
View Article and Find Full Text PDFJanus Films Wound Dressing Comprising Electrospun Gelatin/PCL Nanofibers and Gelatin/Honey/Curcumin Thawed Layer.
ACS Appl Bio Mater
December 2024
Caspian Faculty of Engineering, College of Engineering, University of Tehran, Rezvanshar, Guilan 43861-91836, Iran.
A promising approach for wound treatment is using multilayer wound dressings that offer multifunctional properties. In this study, a bilayered electrospun/hydrogel gelatin-based scaffold integrated with honey and curcumin was developed to treat wounds under an in vivo study. The first layer consisted of an enzymatic cross-linked gelatin hydrogel containing honey and curcumin, which gelatin/PCL nanofibers reinforced.
View Article and Find Full Text PDFInhalable multi-stimulus sensitive curcumin-alginate nanogels for scavenging reactive oxygen species and anti-inflammatory co-ordination to alleviate acute lung injury.
Int J Biol Macromol
December 2024
College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China. Electronic address:
Acute lung injury (ALI) is one of the most common and extremely critical clinical conditions, which progresses with an inflammatory response and overproduction of reactive oxygen species (ROS), leading to oxidative damage to the lungs. Curcumin (Cur) has great potential in treating ALI due to its excellent antioxidant and anti-inflammatory effects. In this study, Cur and alginate were cross-linked by zinc ions and intermolecular hydrogen bonding to form an inhalable aqueous nanogel system to overcome Cur's low solubility and bioavailability.
View Article and Find Full Text PDFEffect of Periodate-Induced Cross-linking on Dual Anticancer Drug Release from Poly(2-isopropyl-2-oxazoline)/Tannic Acid-Based Layer-by-Layer Microparticles.
ACS Omega
September 2024
Department of Chemistry, Middle East Technical University, 06800 Cankaya, Ankara, Türkiye.
Article Synopsis
- This study details the creation and stabilization of layered structures made from a random copolymer (PiPOX-PEI) and tannic acid using a technique called layer-by-layer (LbL) assembly, with further enhancement through cross-linking using sodium periodate (NaIO).
- The multilayers were evaluated for their capability to release two cancer drugs, curcumin (CUR) and doxorubicin (DOX), noting that cross-linking favored DOX release while pH and temperature influenced how these drugs were released.
- The study found that while the combination of DOX and CUR had a synergistic effect on cell death, this effect diminished in cross-linked multilayers, indicating that the method of drug release
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!