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Hedgehog Signalling in the Embryonic Mouse Thymus. | LitMetric
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Hedgehog Signalling in the Embryonic Mouse Thymus.

Alessandro Barbarulo Ching-In Lau Konstantinos Mengrelis Susan Ross Anisha Solanki José Ignacio Saldaña Tessa Crompton

J Dev Biol

Immunobiology Section, UCL Institute of Child Health, London WC1N 1EH, UK.

Published: July 2016

T cells develop in the thymus, which provides an essential environment for T cell fate specification, and for the differentiation of multipotent progenitor cells into major histocompatibility complex (MHC)-restricted, non-autoreactive T cells. Here we review the role of the Hedgehog signalling pathway in T cell development, thymic epithelial cell (TEC) development, and thymocyte-TEC cross-talk in the embryonic mouse thymus during the last week of gestation.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4975939PMC
http://dx.doi.org/10.3390/jdb4030022DOI Listing

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