Background: Basal cell carcinoma (BCC) is the most common cutaneous malignancy. Terminal hair is not routinely removed for assessment of BCCs on the scalp and yet may obscure the true size of scalp BCCs. This can compromise effective management.
Objective: To underscore the importance of removing terminal hair on the scalp for an accurate assessment of clinical margins of BCC on the scalp.
Methods: We report 2 cases of cutaneous BCC arising on the scalp. The size of the malignancies was underestimated because they were masked by hair growth.
Results: Removing terminal hair allowed for a full assessment of the extent of the tumours on hair-bearing scalp, which had been underestimated by 73% to 80% prior to shaving.
Conclusion: Our cases highlight the importance of hair removal for complete assessment of cutaneous malignancy occurring on hair-bearing skin.
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http://dx.doi.org/10.1177/1203475416664036 | DOI Listing |
J Clin Med
December 2024
Department of Dermatology, Medical University of Warsaw, Nowogrodzka 59 Str., 02-014 Warsaw, Poland.
: Minoxidil, in addition to its vasodilatory effect, has also immunomodulatory properties that may be partially responsible for its efficacy in alopecia areata. The aim of the study was to evaluate the efficacy of monotherapy with topical or oral minoxidil in alopecia areata. : A systematic review and meta-analysis of the efficacy of monotherapy with minoxidil in alopecia areata was conducted following the PRISMA guidelines.
View Article and Find Full Text PDFNat Commun
January 2025
School of Biosciences, University of Sheffield, Sheffield, S10 2TN, UK.
The refinement of neural circuits towards mature function is driven during development by patterned spontaneous calcium-dependent electrical activity. In the auditory system, this sensory-independent activity arises in the pre-hearing cochlea and regulates the survival and refinement of the auditory pathway. However, the origin and interplay of calcium signals during cochlear development is unknown in vivo.
View Article and Find Full Text PDFBiochem Biophys Res Commun
January 2025
Department of Systems Biology, Yonsei University, Seoul, 03722, Republic of Korea. Electronic address:
The root epidermis of Arabidopsis (Arabidopsis thaliana) consists of two distinct cell types: hair (H) cells and non-hair (N) cells, whose patterning is regulated by a network of genes. Among these, the WEREWOLF (WER) gene, encoding an R2R3 MYB transcription factor, acts as a master regulator by promoting the expression of key downstream genes, such as GLABRA2 and CAPRICE. However, the mechanisms controlling WER expression have remained largely unexplored.
View Article and Find Full Text PDFMethods Mol Biol
December 2024
University of California - Davis, Department of Environmental Toxicology, Davis, CA, USA.
Hair is a ubiquitous and robust mammalian tissue with biological, clinical, forensic, social, and economic significance. The hair shaft proteome reflects both structural proteins, dominated by cuticular intermediate filament keratins and associated proteins, and proteins involved in the final cellular processes of terminally differentiating corneocytes prior to cornification. These distinct biological processes involve cell maintenance, biosynthesis, senescence, and xenobiotic response.
View Article and Find Full Text PDFHear Res
December 2024
Eaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, MA, United States; Department of Otolaryngology-Head & Neck Surgery, Harvard Medical School, Boston, MA, United States. Electronic address:
Auditory-nerve fibers (ANFs) from a given cochlear region can vary in threshold sensitivity by up to 60 dB, corresponding to a 1000-fold difference in stimulus level, although each fiber innervates a single inner hair cell (IHC) via a single synapse. ANFs with high-thresholds also have low spontaneous rates (SRs) and synapse on the side of the IHC closer to the modiolus, whereas the low-threshold, high-SR fibers synapse on the side closer to the pillar cells. Prior biophysical work has identified modiolar-pillar differences in both pre- and post-synaptic properties, but a comprehensive explanation for the wide range of sensitivities remains elusive.
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