AI Article Synopsis
- A new metallo-β-lactamase gene called blaIMP-27 was found in different strains of Proteus mirabilis from two different areas in the U.S.
- The gene is located in a class 2 integron as the first gene cassette.
- Testing showed the bacteria were resistant to ertapenem but susceptible to aztreonam, piperacillin-tazobactam, and ceftazidime, with ceftazidime being broken down by the IMP-27 enzyme.
Article Abstract
A novel metallo-β-lactamase gene, blaIMP-27, was identified in unrelated Proteus mirabilis isolates from two geographically distinct locations in the United States. Both isolates harbor blaIMP-27 as part of the first gene cassette in a class 2 integron. Antimicrobial susceptibility testing indicated susceptibility to aztreonam, piperacillin-tazobactam, and ceftazidime but resistance to ertapenem. However, hydrolysis assays indicated that ceftazidime was a substrate for IMP-27.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038328 | PMC |
| http://dx.doi.org/10.1128/AAC.02945-15 | DOI Listing |
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