Objectives: is an important cause of STI in men and women. Worldwide evidence suggests a reduction in efficacy of azithromycin treatment due to the prevalence of macrolide resistant The aim of this study was to describe the prevalence of macrolide resistance in patients with a positive test for within our setting.
Methods: Two STI clinics in Stockholm offered tests for as part of a routine care pathway. Positive specimens were analysed for macrolide resistance mediating mutations by sequencing.
Results: During the study period, 171 (7.5%) of 2276 patients had a positive test; 7% of women and 8% of men. Macrolide resistance was detected in 31 (18%) of the positive; treatment with azithromycin within the previous 6 months was strongly associated with macrolide resistance.
Conclusions: The prevalence of macrolide resistance was lower in Sweden than in other Northern European settings. We hypothesise that this observation may be due to use of doxycycline as primary treatment of . The efficacy of empirical treatment is challenged by azithromycin resistant . Clinically available and enhanced diagnostics targeting this pathogen are urgently required. We suggest a test of cure 3-4 weeks after start of azithromycin therapy since macrolide resistance develop during treatment.
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