[This corrects the article DOI: 10.1371/journal.pone.0155069.].
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Anal Methods
January 2025
LGC, Queens Road, Teddington, TW11 0LY, UK.
Products containing cannabidiol (CBD) have become increasingly popular due to consumer-perceived benefits of improving health and well-being. More specifically in the United Kingdom (UK), CBD food products are categorised as . For these products to remain on the market, they must have authorisation from the Food Standards Agency on the basis that they are safe, correctly labelled, and do not contain substances classified under controlled drugs legislation in accordance with any existing or future Home Office guidance.
View Article and Find Full Text PDFClin Drug Investig
January 2025
Medical Science Department, Shionogi & Co., Ltd., Osaka, Japan.
Background: Anti-obesity medications are recommended for patients who do not achieve and maintain weight loss despite lifestyle interventions. S-309309 is a novel oral inhibitor of monoacylglycerol O-acyltransferase 2 being developed as a treatment for obesity.
Objective: The objective of the study was to investigate the safety, clinical pharmacology, pharmacokinetics and pharmacodynamic biomarker of S-309309.
Neuroradiology
January 2025
Department of Neurology, National Institute of Mental Health & Neurosciences (NIMHANS), Hosur Road, Bengaluru, Karnataka, 560029, India.
Purpose: The dentato-rubro-thalamo-cortical tract (DRTC) is considered to play a crucial role across tremor disorders including tremor dominant Parkinson's disease (TDPD) and essential tremor plus (ETP). This study aims to comprehensively evaluate microstructural integrity of the DRTC using single-compartment, i.e.
View Article and Find Full Text PDFSpine (Phila Pa 1976)
January 2025
Teaching and Research Area Experimental Orthopaedics and Trauma Surgery, Uniklinik RWTH Aachen, Aachen, Germany.
Study Design: Biomechanical study by using a multi-body simulation approach.
Objective: Objectification of spinal biomechanics after Vertebral Body Tethering with and without Apical Fusion.
Summary Of Background Data: Vertebral body tethering, a motion preserving surgical technique for correction of adolescent idiopathic scoliosis, is increasingly being used for thoracolumbar curves.
J Med Virol
January 2025
Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Instituto de Investigación Sanitaria Hospital "12 de Octubre" (imas12), Madrid, Spain.
The impact of human cytomegalovirus (HCMV) infection on the mid- and long-term balance between pro-inflammatory and anti-inflammatory cytokines among kidney transplant recipients (KTRs) remains unclear. We measured plasma levels of 12 Th1/Th2-type cytokines (granulocyte-macrophage colony-stimulating factor, interferon-γ, interleukin [IL]-1β, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p70, IL-13, IL-18 and tumor necrosis factor-α) in a cohort of 290 KTRs at four time points through month 12 after transplantation. Cytokine levels at each point were compared according to the previous documentation of HCMV replication by two approaches: "cumulative exposure" from the time of transplantation and "recent exposure" within the 2-3 months preceding cytokine assessment.
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