[This corrects the article DOI: 10.1371/journal.pone.0157038.].
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0161046 | PLOS |
PLoS One
January 2025
Department of Pharmacy, West China Hospital, Sichuan University, Chengdu, China.
There is different administration routes of triamcinolone acetonide (TA) administration for macular edema, but the efficacy ranking remains unclear. The purpose of this study is to assess the efficacy of different administration routes of TA employed in macular edema. PubMed, Medline, Embase, and Cochrane Central Register of Controlled Trials were systematically searched for published articles comparing macular edema in patients with triamcinolone acetonide in different administration.
View Article and Find Full Text PDFStat Med
February 2025
MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
There is a growing number of Phase I dose-finding studies that use a model-based approach, such as the CRM or the EWOC method to estimate the dose-toxicity relationship. It is common to assume that all patients will have similar toxicity risk given the dose regardless of patients' individual characteristics. In many trials, however, some patients' covariates (e.
View Article and Find Full Text PDFEntropy (Basel)
December 2024
Department of Data Science and Artificial Intelligence, Faculty of Information Technology, Monash University, Clayton, VIC 3800, Australia.
Species distribution modeling is fundamental to biodiversity, evolution, conservation science, and the study of invasive species. Given environmental data and species distribution data, model selection techniques are frequently used to help identify relevant features. Existing studies aim to find the relevant features by selecting the best models using different criteria, and they deem the predictors in the best models as the relevant features.
View Article and Find Full Text PDFBrief Bioinform
November 2024
Department of Automation, Xiamen University, Xiang'an South Road, Xiang'an, 361102, Xiamen, Fujian, China.
Understanding cell destiny requires unraveling the intricate mechanism of gene regulation, where transcription factors (TFs) play a pivotal role. However, the actual contribution of TFs, that is TF activity, is not only determined by TF expression, but also accessibility of corresponding chromatin regions. Therefore, we introduce BIOTIC, an advanced Bayesian model with a well-established gene regulation structure that harnesses the power of single-cell multi-omics data to model the gene expression process under the control of regulatory elements, thereby defining the regulatory activity of TFs with variational inference.
View Article and Find Full Text PDFBMC Health Serv Res
January 2025
School of Nursing, University of Washington, Seattle, WA, USA.
Background: The prevalence of diabetes is escalating globally, underscoring the need for comprehensive evidence to inform health systems in effectively addressing this epidemic. The purpose of this study was to examine the patterns of countries' capacity to manage diabetes using latent class analysis (LCA) and to determine whether the patterns are associated with diabetes-related deaths and healthcare costs.
Methods: Eight indicators of country-level capacity were drawn from the World Health Organization Global Health Observatory dataset: the widespread availability of hemoglobin A1C (HbA1c) testing, existence of diabetes registry, national diabetes management guidelines, national strategy for diabetes care, blood glucose testing, diabetic retinopathy screening, sulfonylureas, and metformin in the public health sector.
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