The copper-catalyzed H-F insertion into α-diazocarbonyl compounds is described using potassium fluoride (KF) and hexafluoroisopropanol. Access to complex α-fluorocarbonyl derivatives is achieved under mild conditions, and the method is readily adapted to radiofluorination with [(18)F]KF. This late-stage strategy provides an attractive route to (18)F-labeled biomolecules.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9011916 | PMC |
| http://dx.doi.org/10.1021/jacs.6b06770 | DOI Listing |
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