It is widely believed that damaged axons in the adult mammalian brain have little capacity to regrow, thereby impeding functional recovery after injury. Studies using fixed tissue have suggested that serotonin neurons might be a notable exception, but remain inconclusive. We have employed in vivo two-photon microscopy to produce time-lapse images of serotonin axons in the neocortex of the adult mouse. Serotonin axons undergo massive retrograde degeneration following amphetamine treatment and subsequent slow recovery of axonal density, which is dominated by new growth with little contribution from local sprouting. A stab injury that transects serotonin axons running in the neocortex is followed by local regression of cut serotonin axons and followed by regrowth from cut ends into and across the stab rift zone. Regrowing serotonin axons do not follow the pathways left by degenerated axons. The regrown axons release serotonin and their regrowth is correlated with recovery in behavioral tests.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4990493 | PMC |
| http://dx.doi.org/10.1016/j.neuron.2016.07.024 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Functional Regrowth of Norepinephrine Axons in the Adult Mouse Brain Following Injury.
eNeuro
December 2024
Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA.
It is widely believed that axons in the central nervous system of adult mammals do not regrow following injury. This failure is thought, at least in part, to underlie the limited recovery of function following injury to the brain or spinal cord. Some studies of fixed tissue have suggested that, counter to dogma, norepinephrine (NE) axons regrow following brain injury.
View Article and Find Full Text PDFSerotonin Inhibition of Claustrum Projection Neurons: Ionic Mechanism, Receptor Subtypes and Consequences for Claustrum Computation.
Cells
November 2024
Neuroscience & Mental Health Program, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore.
The claustrum is a small but densely interconnected brain structure that is innervated by axons containing serotonin (5-HT), a neuromodulator that has been implicated in control of sleep and in the actions of psychedelic drugs. However, little is known about how 5-HT influences the claustrum. We have combined whole-cell patch-clamp measurements of ionic currents, flash photolysis, and receptor pharmacology to characterize the 5-HT responses of individual claustral projection neurons (PNs) in mouse brain slices.
View Article and Find Full Text PDFSynchronous activation of striatal cholinergic interneurons induces local serotonin release.
bioRxiv
December 2024
Department of Medical Neurobiology, Institute of Medical Research Israel - Canada, Faculty of the Medicine, The Hebrew University of Jerusalem, Jerusalem, 9112102, Israel.
Striatal cholinergic interneurons (CINs) activate nicotinic acetylcholine receptors on dopamine axons to extend the range of dopamine release. Here we show that synchronous activation of CINs induces and extends the range of local serotonin release via a similar mechanism. This process is exaggerated in the hypercholinergic striatum of a mouse model of OCD-like behavior, implicating CINs as critical regulators of serotonin levels in the healthy and pathological striatum.
View Article and Find Full Text PDFStructural Basis for Histaminergic Regulation of Neural Circuits in the Mouse Olfactory Bulb.
J Comp Neurol
October 2024
Department of Anatomy, Kawasaki Medical School, Kurashiki, Okayama, Japan.
Article Synopsis
- A study examines how histamine-producing neurons from the hypothalamus influence the olfactory bulb (OB), a key area for processing smells.
- Researchers used advanced microscopy techniques to visualize these neurons and their connections, discovering that they have unique synaptic relationships with other neurons in the OB.
- The findings suggest that histamine may play an important role in odor discrimination, highlighting a link between brain regions that control hunger and olfactory function.
Serotonergic modulation of swallowing in a complete fly vagus nerve connectome.
Curr Biol
October 2024
Department of Molecular Brain Physiology and Behavior, LIMES Institute, University of Bonn, Carl-Troll-Straße, Bonn 53115, Germany. Electronic address:
How the body interacts with the brain to perform vital life functions, such as feeding, is a fundamental issue in physiology and neuroscience. Here, we use a whole-animal scanning transmission electron microscopy volume of Drosophila to map the neuronal circuits that connect the entire enteric nervous system to the brain via the insect vagus nerve at synaptic resolution. We identify a gut-brain feedback loop in which Piezo-expressing mechanosensory neurons in the esophagus convey food passage information to a cluster of six serotonergic neurons in the brain.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!