The course of severe acute and chronic odontogenic purulent inflammatory staphylococcal disorders involves the depression of cellular (myeloperoxidase, cation proteins of the neutrophilic leucocytes) and humoral (hemolytic complement and the blood serum bacteriostatic activities) antigen-independent immune factors. The differentiated immunomodulating therapy is recommended in such cases.
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Cancer Res Commun
October 2024
Department of Neurosurgery, Duke University School of Medicine, Durham, North Carolina.
Unlabelled: Mounting evidence links systemic innate immunity with cancer immune surveillance. In advanced metastatic castration-resistant prostate cancer (mCRPC), Black patients have been found to have increased inflammatory markers and longer survival after sipuleucel-T (sip-T) therapy, an FDA-approved, autologous cell therapy. We hypothesized these differences may be explained by previously reported ancestral differences in pattern recognition receptor signaling, which broadly governs innate inflammation to control adaptive immune cell activation, chemotaxis, and functionality.
View Article and Find Full Text PDFCancer Immunol Res
October 2024
Memorial Sloan Kettering Cancer Center, New York, New York.
Chimeric antigen receptor (CAR) T-cell therapy has resulted in remarkable clinical success in the treatment of B-cell malignancies. However, its clinical efficacy in solid tumors is limited, primarily by target antigen heterogeneity. To overcome antigen heterogeneity, we developed CAR T cells that overexpress LIGHT, a ligand of both lymphotoxin-β receptor on cancer cells and herpes virus entry mediator on immune cells.
View Article and Find Full Text PDFEur J Immunol
September 2024
Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.
Nat Cancer
May 2024
Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Chimeric antigen receptor T cells have dramatically improved the treatment of hematologic malignancies. T cell antigen receptor (TCR)-based cell therapies are yet to achieve comparable outcomes. Importantly, chimeric antigen receptors not only target selected antigens but also reprogram T cell functions through the co-stimulatory pathways that they engage upon antigen recognition.
View Article and Find Full Text PDFAm J Physiol Renal Physiol
May 2024
Division of Cardiothoracic Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States.
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