AI Article Synopsis
Article Abstract
Rapidly adapting (RA) currents expressed in dorsal root ganglia somatosensory neurons reduce their amplitude in response to prolonged and/or repeated mechanical stimulation. Both inactivation of mechanotransducer channels and adaptation of the force acting on the channels have been suggested to independently decrease RA currents. However, these two mechanisms have similar kinetics and dependence on calcium and voltage. These experimental findings suggest that a single mechanism might underlie both. We constructed a simple Hodgkin-Huxley-type model with a single gating variable driving both inactivation and adaptation to test this hypothesis. Predictions of the model successfully describe key features of mechanical activation as well as inactivation, adaptation, and recovery. The model thus supports the possibility of a single mechanism driving inactivation and adaptation in RA currents. On its own, the model can be integrated into higher-order models of touch receptors because of its accurate simulation of RA currents.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00422-016-0693-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Eradication of single- and mixed-species biofilms of P. aeruginosa and S. aureus by pulsed streamer corona discharge cold atmospheric plasma.
Sci Total Environ
December 2024
Division of Environmental Physics, Faculty of Mathematics, Physics and Informatics, Comenius University, 842 48 Bratislava, Slovakia.
Cold atmospheric plasma has recently gained much attention due to its antimicrobial effects. Among others, plasma has proven its potential to combat microbial biofilms. Yet, knowledge of complex network interactions between individual microbial species in natural infection environments of the biofilm as well as plasma-biofilm inactivation pathways is limited.
View Article and Find Full Text PDFAttenuated sex-related DNA methylation differences in cancer highlight the magnitude bias mediating existing disparities.
Biol Sex Differ
December 2024
State Key Laboratory of Genetic Engineering, School of Life Sciences, Human Phenome Institute, Fudan University, Shanghai, China.
Background: DNA methylation (DNAm) influences both sex differences and cancer development, yet the mechanisms connecting these factors remain unclear.
Methods: Utilizing data from The Cancer Genome Atlas, we conducted a comprehensive analysis of sex-related DNAm effects in nine non-reproductive cancers, compared to paired normal adjacent tissues (NATs), and validated the results using independent datasets. First, we assessed the extent of sex differential DNAm between cancers and NATs to explore how sex-related DNAm differences change in cancerous tissues.
Extra X, extra questions: Trisomy X syndrome and IgA deficiency - a case report.
Front Immunol
December 2024
Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Rome, Italy.
While Trisomy X syndrome is typically characterized by developmental and cognitive variations, it is not commonly associated with immunodeficiencies. We report the unique case of a 6-year-old girl with Trisomy X presenting with selective IgA deficiency, challenging the conventional understanding of this chromosomal condition. The patient exhibited recurrent respiratory infections and gastrointestinal symptoms, evaluated in the context of her genetic background of Trisomy X and significantly low levels of IgA (0.
View Article and Find Full Text PDFEvaluation of yeast-based additives on rumen fermentation in high- and low-concentrate diets using a dual-flow continuous culture system.
Transl Anim Sci
December 2024
Institute of Animal Science, Beef Cattle Research Center, Sertãozinho, Brazil.
The objective of this study was to evaluate the efficacy of using 3 yeast-based additives as an alternative to sodium monensin on rumen fermentation parameters using a dual-flow continuous fermentation system. Ten fermenters (1,223 ± 21 mL) were used in 2 simultaneous 5 × 5 Latin squares arrangement with 3 periods of 10 d each, with 7 d for diet adaptation and 3 d for sample collections. Each Latin square assigning either a low or high level of concentrate to beef cattle diets, with 5 specified treatments: Control: no additives; Blend 1: yeast culture (), beta-glucans, fructooligosaccharides, galactooligosaccharides, and mannanoligosaccharides [1,600 mg/kg dry matter (DM)]; Blend 2: Beta-glucan and mannanoligosaccharide fractions from (1,600 mg/kg DM); Yeast Cells: hydrolyzed, inactivated, and spray-dried yeast cells (; 2,133 mg/kg DM); monensin (25 mg/kg DM).
View Article and Find Full Text PDFDetermination of hepatitis E virus inactivation during manufacturing of spreadable pork liver sausage and salami-like raw pork sausage.
Int J Food Microbiol
December 2024
German Federal Institute of Risk Assessment, Max-Dohrn-Straße 8-10, 10589 Berlin, Germany. Electronic address:
The zoonotic hepatitis E virus (HEV) can cause acute and chronic hepatitis in humans. Meat from domestic pigs, which represent a major animal reservoir of HEV, plays a key role in HEV transmission. Although pork meat products can contain HEV-RNA, it is unknown whether infectious HEV is still present after their manufacturing process.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!