Objectives: To assess respective roles of serum creatinine (SCr) alone and estimated glomerular filtration rate (eGFR) as an early predictor for contrast-induced nephropathy (CIN) in elderly patients with cancer.
Materials And Methods: eGFR of 348 patients at 65years or older with malignancy who underwent contrast-enhanced computed tomography (CECT) were calculated. eGFR was calculated based on the following three equations: Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI); Modification of Diet in Renal Disease Study (MDRD); Cockcroft-Gault (CG). CIN was subdivided into two groups: CIN (SCr increase >25% but ≤0.5mg/dl), and CIN (SCr increase >0.5mg/dl). The occurrence and clinical outcomes of CIN were determined according to SCr and eGFR.
Results: After CECT, CIN occurred in 50 (14.4%) patients, including 33 CIN patients and 17 CIN patients. CIN was significantly correlated with prolonged hospitalizations and increased in-hospital mortality, but not CIN. Despite SCr<1.5mg/dl, preexisting renal insufficiency (RI) was observed in 47 (13.5%) patients based on CKD-EPI equation, 50 (14.4%) patients based on MDRD equation, and 144 (41.4%) patients based on CG formula. In preexisting RI, the prevalence of CIN had an odds ratio of 15.02 (5.24 to 43.07) based on CKD-EPI equation, 13.73 (4.81 to 39.20) based on MDRD equation, and 5.03 (1.60 to 15.75) based on CG formula.
Conclusion: In elderly patients with cancer who visit the emergency department, renal assessment before CECT using CKD-EPI equation was superior to SCr alone, MDRD equation, or CG formula in predicting the occurrence of CIN related CECT.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jgo.2016.07.012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Influence of Digital Health Literacy on Blood Pressure and Hemoglobin A1c in Patients With Comorbid Type 2 Diabetes and Hypertension.
Comput Inform Nurs
January 2025
Author Affiliations: Duke University School of Nursing (Drs Lee, Silva, Yang, Hatch, and Shaw and Mss Pennington, Matters, and Urlichich); and Duke University School of Medicine (Dr Crowley), Durham, NC.
Digital health literacy is emerging as an important element in chronic illness management, yet its relationship with clinical outcomes remains unclear. Utilizing data from the ongoing EXpanding Technology-Enabled, Nurse-Delivered Chronic Disease Care trial, this cross-sectional, correlational study explored the association between digital health literacy, health literacy, and patient outcomes, specifically blood pressure and hemoglobin A1c levels in 76 patients managing comorbid type 2 diabetes and hypertension. Results indicate patients had moderate digital health literacy, which was not significantly correlated with health literacy (r = 0.
View Article and Find Full Text PDFApplying Results of Extended Genotyping to Management of Positive Cervicovaginal Human Papillomavirus Test Results: Enduring Guidelines.
J Low Genit Tract Dis
January 2025
Division of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, MD.
Objective: The Enduring Consensus Cervical Cancer Screening and Management Guidelines Committee developed recommendations for the use of extended genotyping results in cervical cancer prevention programs.
Methods: Risks of cervical intraepithelial neoplasia grade 3 or worse were calculated using data obtained with the Onclarity HPV Assay from large cohorts. Management recommendations were based on clinical action thresholds developed for the 2019 American Society for Colposcopy and Cervical Pathology Risk-Based Management Consensus Guidelines.
Identification of apoptosisrelated long noncoding RNAs expression profiles in patient with cervical intraepithelial neoplasia 3.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
July 2024
Department of Laboratory Medicine, Second Xiangya Hospital, Central South University, Changsha 410011.
Objectives: Long non-coding RNAs (lncRNAs) play an essential role in cancer biology. Cervical intraepithelial neoplasia grade 3 (CIN3) is the most severe precancerous lesion of cervical cancer. However, the mechanism of multiple lncRNAs in CIN3 has not been studied in-depth and is worth exploring.
View Article and Find Full Text PDFDesign, Development, and Evaluation of a 3D-Printed Buccal Myomucosal Flap Simulator.
Cleft Palate Craniofac J
January 2025
Department of Otolaryngology-Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, MI, USA.
Objective: Buccal myomucosal flap procedures have become a critical tool in the armamentarium of the cleft surgeon. Mastering this technique is complex and providing sufficient training opportunities presents significant challenges. Our study details the design, development, and evaluation of a low-cost, high-fidelity buccal myomucosal flap surgical simulator.
View Article and Find Full Text PDFCinnamaldehyde nanoemulsion decorated with rhamnolipid for inhibition of methicillin-resistant biofilm formation: and assessment.
Front Microbiol
December 2024
College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, China.
Background: () biofilm associated infections are prevalent and persistent, posing a serious threat to human health and causing significant economic losses in animal husbandry. Nanoemulsions demonstrate significant potential in the treatment of bacterial biofilm associated infections due to their unique physical, chemical and biological properties. In this study, a novel cinnamaldehyde nanoemulsion with the ability to penetrate biofilm structures and eliminate biofilms was developed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!