Objective: Natural history of paediatric-onset ulcerative proctitis (UP) is poorly described. Our aim was to describe the phenotype and disease course of incident UP in a population-based study of paediatric-onset UC.
Patients And Methods: All patients with UC diagnosed <17 years from 1988 to 2004, and followed during >2 years have been extracted from a population-based registry. UC location was defined according to the Paris classification. Cumulative risks for use of immunosuppressants (IS), anti-tumour necrosis factor alpha (TNF-α) therapy, colonic extension and colectomy were described using Kaplan-Meier method. Risk factors for colonic extension were assessed using Cox proportional hazards models.
Results: 158 patients with paediatric-onset UC (91 females) with a median age at diagnosis of 14.5 years (Q1: 11.4-Q3: 16.1) have been identified and followed during a median of 11.4 years (8.2-15.8). Among them, 25% had UP (E1) at diagnosis and 49% of them presented a colonic extension at maximal follow-up. In these children, the cumulative risk for colonic extension was 10% at 1 year, 45% at 5 years and 52% at 10 years. No parameter at diagnosis was associated with colonic extension in the UP (E1 group). IS use was significantly lower in patients with UP than in those with E2, E3 or E4 location (p=0.049). For the UP cohort, the cumulative risk for colectomy was 3% at 1 year, 10% at 5 years, 13% at 10 years and 13% at 15 years. Risks for colonic extension, treatment with anti-TNF-α and colectomy did not differ between the E1 group and the E2-E3-E4 group.
Conclusions: UP is frequent in paediatric-onset UC and should not be considered as a minor disease. Compared with more extensive UC locations, risks for colonic extension, anti-TNF-α therapy and colectomy were similar in UP, whereas the risk for use of IM was lower.
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http://dx.doi.org/10.1136/gutjnl-2016-311970 | DOI Listing |
Polymers (Basel)
December 2024
Centro de Física de Materiales (CSIC-UPV/EHU)-Materials Physics Center (MPC), P. M. de Lardizábal 5, 20018 San Sebastián, Spain.
This work connects the calorimetric responses of different rubber-resin blends with varying resin contents with their alpha relaxation dynamics. We used differential scanning calorimetry and broadband dielectric spectroscopy to characterize the calorimetric and dielectric responses of styrene-butadiene, polybutadiene, and polyisoprene with different resin contents. To model the results, we used the Gordon-Taylor equation combined with an extension of the Adam-Gibbs approach.
View Article and Find Full Text PDFPharmaceuticals (Basel)
November 2024
Laboratory of Nanobiotechnologies, Saint-Petersburg National Research Academic University of the Russian Academy of Sciences, Saint Petersburg 194021, Russia.
: A series of spiro-fused heterocyclic compounds containing cyclopropa[a]pyrrolizidine-2,3'-oxindole and 3-spiro[3-azabicyclo[3.1.0]-hexane]oxindole frameworks were synthesized and studied for their in vitro antiproliferative activity against human erythroleukemia (K562), cervical carcinoma (HeLa), acute T cell leukemia (Jurkat), melanoma (Sk-mel-2) and breast cancer (MCF-7) as well as mouse colon carcinoma (CT26) cell lines.
View Article and Find Full Text PDFBiochim Biophys Acta Mol Basis Dis
December 2024
Department of Pharmacy, Uppsala University, Box 580, SE-751 23 Uppsala, Sweden; Gastroenterology Research Group, Department of Medical Sciences, Uppsala University Hospital, SE-751 85 Uppsala, Sweden. Electronic address:
Psoriasis is a chronic skin disease occasionally associated with abdominal symptoms and IBD. We aimed to characterize intestinal immune cells and the integrity of the intestinal barrier in psoriasis. Biopsies from the duodenum and colon were analyzed by flow cytometry and immunohistochemistry for the presence and activation status of different immune cell populations.
View Article and Find Full Text PDFACS Appl Mater Interfaces
December 2024
Instituto de Investigaciones en Ciencia y Tecnología de Materiales (INTEMA), CONICET/UNMdP, Av. Colón 10850, B7606BWV, Mar del Plata, Argentina.
This study addresses the extension of the service life of carbon-fiber reinforced epoxies by inducing thermal healing of microcracks through the use of a vitrimer as a polymeric matrix. Our aim was to explore the feasibility of using a blend of selected carboxylic acids (citric, glutaric, and sebacic acids) and commercial monomers to design a matrix specifically developed for technological implementation in composites with the ability of intrinsic repair of microcracks under moderate (even remote) heating treatments. The selection of the formulation (the acid blend, catalysts, and monomers) was the result of an exhaustive prescreening analysis of processing requisites and final properties.
View Article and Find Full Text PDFBMJ Case Rep
December 2024
Otorhinolaryngology, IPO Coimbra, Coimbra, Portugal.
Bevacizumab, a monoclonal antibody targeting vascular endothelial growth factor receptors, has become a widely used treatment for various types of cancer, including metastatic colorectal cancer. However, while the benefits of bevacizumab in improving survival outcomes have been well-documented, it is important to consider the potential adverse effects associated with this therapy. We report a case of a male patient in his 50s with a history of metastatic colorectal cancer who began a regimen of bevacizumab in combination with chemotherapy.
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