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| http://dx.doi.org/10.1111/exd.13150 | DOI Listing |
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Myelin protein zero-like 3 (MPZL3) is an Immunoglobulin-containing transmembrane protein with predicted cell adhesion molecule function. Loss of 11q23, where the gene resides, is frequently observed in cancer, and copy number alterations are frequently detected in tumor specimens. Yet the role and consequences of altered MPZL3 expression have not been explored in tumor development and progression.
View Article and Find Full Text PDFMet-HER3 crosstalk supports proliferation via MPZL3 in MET-amplified cancer cells.
Cell Mol Life Sci
March 2022
Rosalind and Morris Goodman Cancer Institute, McGill University, Montréal, QC, Canada.
Receptor tyrosine kinases (RTKs) are recognized as targets of precision medicine in human cancer upon their gene amplification or constitutive activation, resulting in increased downstream signal complexity including heterotypic crosstalk with other RTKs. The Met RTK exhibits such reciprocal crosstalk with several members of the human EGFR (HER) family of RTKs when amplified in cancer cells. We show that Met signaling converges on HER3-tyrosine phosphorylation across a panel of seven MET-amplified cancer cell lines and that HER3 is required for cancer cell expansion and oncogenic capacity in vitro and in vivo.
View Article and Find Full Text PDFLoss of MPZL3 function causes seborrhoeic dermatitis-like phenotype in mice.
Exp Dermatol
August 2017
Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Epigenetic patterns in successful weight loss maintainers: a pilot study.
Int J Obes (Lond)
May 2015
Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
DNA methylation changes occur in animal models of calorie restriction, simulating human dieting, and in human subjects undergoing behavioral weight loss interventions. This suggests that obese (OB) individuals may possess unique epigenetic patterns that may vary with weight loss. Here, we examine whether methylation patterns in leukocytes differ in individuals who lost sufficient weight to go from OB to normal weight (NW; successful weight loss maintainers; SWLMs) vs currently OB or NW individuals.
View Article and Find Full Text PDFLoss of Mpzl3 function causes various skin abnormalities and greatly reduced adipose depots.
J Invest Dermatol
July 2014
Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida, USA; Molecular Cell and Developmental Biology, Graduate Program in Biomedical Sciences, University of Miami Miller School of Medicine, Miami, Florida, USA; Cancer Epidemiology and Prevention Program, Sylvester Comprehensive Cancer Center, University of Miami Health System, Miami, Florida, USA. Electronic address:
The rough coat (rc) spontaneous mutation causes sebaceous gland (SG) hypertrophy, hair loss, and extracutaneous abnormalities including growth retardation. The rc mice have a missense mutation in the predicted Ig protein Myelin Protein Zero-Like 3 (Mpzl3). In this study, we generated Mpzl3 knockout mice to determine its functions in the skin.
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