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Braz J Psychiatry
March 2025
Affiliated Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, Jiangsu, China.
Objective: This study aimed to mine and analyze adverse event signals of fluoxetine using the FAERS database.
Methods: This study focused on suspected drug adverse reaction reports from the first quarter of 2004 to the second quarter of 2023, with fluoxetine as the primary suspected drug. Four signal mining and analysis methods were employed to comprehensively assess adverse event signals.
Braz J Psychiatry
March 2025
Center for Drug and Alcohol Research, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Graduate Program in Psychiatry and Behavioral Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Objective: To determine severity clusters (groups) of substance use in crack cocaine users by the severity scores of the sixth version of the Addiction Severity Index (ASI-6) and compare the groups detected in relation to risk factors as parental styles, childhood maltreatment, and impulsivity.
Methods: A cross-sectional study was conducted with 531 male adults with Substance Use Disorder, admitted to a hospital treatment unit for addiction in Southern Brazil. In order to detect more homogeneous groups of individuals, the approach used involves the K-means clustering using ASI-6 scores to create clusters or groups of individuals with similar severity in different areas.
Braz J Psychiatry
March 2025
Department of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, Ghent, Belgium. Ghent Experimental Psychiatry (GHEP) Lab, Ghent University, Ghent, Belgium.
Depression is a common and debilitating disorder affecting millions. First-line treatments fail to achieve remission in about one-third of patients, highlighting a critical treatment need. Transcranial direct current stimulation (tDCS) has emerged as a novel treatment for depression.
View Article and Find Full Text PDFBraz J Psychiatry
March 2025
Service of Interdisciplinary Neuromodulation, Laboratory of Neurosciences (LIM-27), Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil. Service of Electroconvulsive Therapy, Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Background: Convulsive therapies are often effective for Treatment-Resistant Depression (TRD), although their mechanisms of action are unclear. Increases in Brain-Derived Neurotrophic Factor (BDNF) levels are observed after Electroconvulsive Therapy (ECT), but more recent evidence calls this claim into question. Moreover, Magnetic Seizure Therapy (MST), a new convulsive technique, has not yet been studied regarding possible neurotrophic modulation.
View Article and Find Full Text PDFRadiol Phys Technol
March 2025
Department of Neurosurgery, Division of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, 5200 Kihara Kiyotake-Cho, Miyazaki, 889-1692, Japan.
This study addresses the growing concerns of increased radiation doses to patients resulting from the increased complexity of interventional radiology procedures. Despite the importance of dose management, few facilities use dosimetry systems to measure and control patient radiation doses. To aid in patient exposure control, this research aimed to predict the peak skin dose (PSD) using dose parameters from digital imaging and communication in medicine-radiation dose structured reports.
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