Nevada Center for Biomedical ResearchReno, NV, USA; Department of Biochemistry and Molecular Biology, University of NevadaReno, NV, USA.
Published: August 2016
AI Article Synopsis
Article Abstract
Hantavirus infection is associated with two frequently fatal diseases in humans: Hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). The pathogenesis of hantavirus infection is complex and not fully understood; however, it is believed to involve virus-induced hyperinflammatory immune responses. Thrombospondin-1 (THBS1) is a large homotrimeric protein that plays a putative role in regulating blood homeostasis. Hyperresponsiveness to inflammatory stimuli has also been associated with defects in the THBS1 gene. Our data suggest that hantavirus infection of human umbilical cord vein endothelial cells (HUVEC) suppress the accumulation of THBS1 in the extracellular matrix. Additionally, this suppression is dependent on virus replication, implying a direct mechanism of action. Our data also imply that the pathogenic Andes and Hantaan strains inhibit THBS1 expression while the non-pathogenic Prospect Hill strain showed little inhibition. These observations suggest that a dysregulation of THBS1 may contribute to the pathogenesis of hantavirus infection.
Laboratorio de Ecología Evolutiva y Biogeografía (LEEB) - Instituto de Ecorregiones Andinas-Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) - Universidad Nacional de Jujuy (UNJu), Gorriti 237, San Salvador de Jujuy, Jujuy, Argentina. Electronic address:
Hantavirus Pulmonary Syndrome (HPS) is a Pan-American emerging infectious disease with a high mortality rate caused by rodent-borne viruses of the genus Orthohantavirus. In Argentina, almost half of the HPS infections occur in the northwestern endemic region. In this study, we evaluated rodent composition, abundance, and antibody prevalence in wild rodents in three subtropical sites: primary forest, secondary forest, and crop fields.
Background: Bat-borne hantaviruses have been identified worldwide but little is known about neotropical bats in the megadiverse biomes of the American continent. Although serological evidence has hinted at hantavirus circulation in Brazil, the scarce number of genomic detection represents a gap to understand viral diversity, prevalence, and ecology of bat-borne hantaviruses.
Objective: We aim to investigate and evaluate the presence and prevalence of bat-borne hantavirus in the Brazilian Atlantic Forest.
School of Medicine, Institute of Graduate, Center for Tropical Medicine and Infectious Disease Research, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Background: Leptospirosis (LS) and hantavirus (HV) are rodent-borne diseases and share similar clinical manifestations, posing diagnostic challenges.
Methods: This retrospective study compared clinical characteristics, laboratory data, complications and outcomes of 33 LS and nine HV cases in Kaohsiung, Taiwan, from 2006 to 2021.
Results: Both LS and HV diseases had high rates of acute kidney injury (84.
Hantaviridae is a family of RNA viruses that includes pathogens affecting humans and animals, and they contain a polymerase essential for their genome replication.
The study focuses on the expression and purification of the polymerase from the Hantaan virus, utilizing Cryo-EM to explore its structure in detail, achieving resolutions between 2.7 to 3.3 Å.
Important findings include the identification of new conformations of the polymerase and the observation of its interaction with RNA and nucleotides, which provide insights into its transcription and replication mechanism, paving the way for potential therapeutic developments.
Hemorrhagic fever with renal syndrome (HFRS), caused by Orthohantavirus hantanense, presents with symptoms like fever and kidney issues, but can also involve rare conditions like acute pancreatitis and leukemoid reaction.
A case study of a 20-year-old male showed severe symptoms that led to hospitalization and a positive HTNV antibody test, highlighting the challenges in diagnosing HFRS when symptoms are atypical.
The study stresses the need for healthcare professionals to identify unusual HFRS symptoms early and use a comprehensive treatment approach to enhance patient outcomes, especially in areas where the disease is common.
