There is little scientific evidence on the local use of Mangifera indica in kidney diseases. This study investigated the reno-modulatory roles of the aqueous stem bark extract of Mangifera indica (MIASE) against CCl4-induced renal damage. Rats were treated intragastrically with 125, 250 and 500 mg/kg/day MIASE for 7 days before and after the administration of CCl4 (3 ml/kg of 30% CCl4, i.p.). Serum levels of electrolytes (Na+, K+, Cl(-), HCO3(-)), urea and creatinine were determined. Renal tissue reduced glutathione (GSH), malondialdehyde (MDA), catalase (CAT), superoxide (SOD) activities were also assessed. The histopathological changes in kidneys were determined using standard methods. In CCl4 treated rats the results showed significant (p<0.05) increases in serum Na+, K+, Cl(-), urea and creatinine. CCl4 also caused significant (p<0.05) decreases in renal tissue SOD, CAT and GSH and significant (p<0.05) increases in MDA. The oral MIASE treatment (125-500 mg/kg) was found to significantly (p<0.05) attenuate the increase in serum electrolytes, urea and creatinine. Similarly, MIASE significantly (p<0.05) attenuated the decrease in SOD, CAT and GSH levels and correspondingly attenuated increases in MDA. Mangifera indica may present a great prospect for drug development in the management of kidney disease with lipid peroxidation as its etiology.
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http://dx.doi.org/10.1515/intox-2015-0027 | DOI Listing |
J Food Sci
January 2025
College of Agriculture, Food, Climate Science, Injibara University, Injibara, Ethiopia.
Mangoes (Mangifera indica L.) are valued for their rich nutrients, including vitamins A, B, C, carotenoids, and phenolic compounds. However, high moisture content and seasonal availability contribute to post-harvest losses of up to 50%.
View Article and Find Full Text PDFPLoS One
January 2025
Bioinformatics Laboratory (BioLab), Noakhali, Bangladesh.
The rare zoonotic Borna disease virus (BDV) causes fatal neurological disease in various animals, with a high mortality rate exceeding 90% in central Europe. However, unlike most viruses, it establishes persistent infections within the host cell nucleus, hindering treatment. As successful BDV treatments remain elusive, the researchers turned to a computational approach, utilizing molecular docking, ADME/T, post-docking MMGBSA, MD simulation, DCCM, and PCA to identify promising phytochemical drug candidates targeting the BDV Nucleoprotein (PDB ID: 1N93).
View Article and Find Full Text PDFInt J Mol Sci
December 2024
National Key Laboratory for Tropical Crop Breeding, Key Laboratory of Tropical Fruit Biology, Ministry of Agriculture and Rural Affairs, Key Laboratory of Hainan Province for Postharvest Physiology and Technology of Tropical Horticulture Products, South Subtropical Crops Research Institute, Chinese Academy of Tropical Agricultural Sciences, Zhanjiang 524013, China.
Mango ( L.) (2n = 40) is an important perennial fruit tree in tropical and subtropical regions. The lack of information on genetic diversity at the molecular level hinders efforts in mango genetic improvement and molecular marker-assisted breeding.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Botany, Government College Women University, Sialkot, Pakistan.
The phytochemical fingerprinting that add to the nutritional and nutraceutical value of the fruits during the ripening stages is beneficial for human consumption. Therefore, ripening-dependent changes in phytochemical content and antioxidant activities of mango (Mangifera indica L.) cultivar Dusehri at various ripening stages were evaluated.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Botany and Microbiology, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia.
Salinity stress disrupts water uptake and nutrient absorption, causing reduced photosynthesis, stunted growth, and decreased crop yields in plants. The use of indole acetic acid (IAA), arginine (AN), and mango fruit waste biochar (MFWB) can be effective methods to overcome this problem. Indole acetic acid (IAA) is a natural auxin hormone that aids cell elongation and division, thereby increasing plant height and branching.
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