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CAIP-Induced ROS Production Contributes to Sustaining Atherosclerotic Process Associated with Infection through Macrophages and Endothelial Cells Activation.
Int J Mol Sci
August 2024
Department of Biology, University of Padova, 35131 Padova, Italy.
Several lines of evidence have linked the intestinal bacterium with the pathogenesis of atherosclerosis, identifying the Cinaedi Antigen Inflammatory Protein (CAIP) as a key virulence factor. Oxidative stress and inflammation are crucial in sustaining the atherosclerotic process and oxidized LDL (oxLDL) uptake. Primary human macrophages and endothelial cells were pre-incubated with 10 µM diphenyl iodonium salt (DPI) and stimulated with 20 µg/mL CAIP.
View Article and Find Full Text PDFPeritonsillar abscess associated with bacteremia: A case report.
IDCases
April 2024
Department of General Medicine, Nerima Hikarigaoka Hospital, 2-5-1 Hikarigaoka Nerima-ku, Tokyo 179-0072, Japan.
Helicobacter cinaedi, a gram-negative spiral bacterium, has historically been associated with infections primarily in immunocompromised patients. Recently, however, its potential to cause infections in immunocompetent individuals has been recognized. We report a unique case of a man in his 20 s who reported having sex with men.
View Article and Find Full Text PDFis a genus of spiral-shaped Gram-negative enterohepatic bacteria whose members are capable of causing bacteremia in humans. One of the poorly studied members of this genus is the bacterium . This microorganism was first isolated from human fecal samples in 1984.
View Article and Find Full Text PDFRacial disparities in metastatic colorectal cancer outcomes revealed by tumor microbiome and transcriptome analysis with bevacizumab treatment.
Front Pharmacol
January 2024
Department of Otorhinolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Metastatic colorectal cancer (mCRC) is a heterogeneous disease, often associated with poor outcomes and resistance to therapies. The racial variations in the molecular and microbiological profiles of mCRC patients, however, remain under-explored. Using RNA-SEQ data, we extracted and analyzed actively transcribing microbiota within the tumor milieu, ensuring that the identified bacteria were not merely transient inhabitants but engaged in the tumor ecosystem.
View Article and Find Full Text PDFHelicobacter cinaedi Bacteremia in Children: A Case Report and Literature Review.
Pediatr Infect Dis J
April 2024
Infectious Diseases Unit, Department of Pediatrics, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Ein Karem, Jerusalem, Israel.
Helicobacter cinaedi is known to cause invasive infections in immunocompromised adults. Here we report the first case of H. cinaedi bacteremia in a child with nephrotic syndrome.
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