The Research to Practice column is intended to improve the research critique skills of the advanced practice registered nurse and emergency nurse (RN) and to assist with the translation of research into practice. For each column, a topic and a research study are selected. The stage is set with a case presentation. The research article is then reviewed and critiqued, and the findings are discussed in relation to the case presented. In the current column, we examine the findings of from their article, titled "Two Days of Dexamethasone Versus 5 Days of Prednisone in the Treatment of Acute Asthma: A Randomized Controlled Trial."
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| http://dx.doi.org/10.1097/TME.0000000000000109 | DOI Listing |
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Fetal radiation during acetabular and pelvic ring fixation: Which injury patterns dictate dangerous levels of fluoroscopic cumulative dose.
J Clin Orthop Trauma
March 2025
Department of Orthopaedic Surgery, Mercy St. Vincent Medical Center, 2213 Cherry St., Toledo, OH, 43608, USA.
Background: Gravid females with pelvic fractures are rarely encountered by the orthopaedic trauma surgeon. The initial injury can be detrimental to the pregnant patient, but an unnecessary "second hit" from surgery could also contribute to the outcome of the fetus. Understanding the surgical risks for this unique patient population requires knowledge about the negative effects of anesthesia, surgical exposures, and radiation.
View Article and Find Full Text PDFDevelopment and validation of a sensitive LC-MS/MS assay for determination of upadacitinib in human plasma and its application in patients with inflammatory bowel disease.
J Pharmacol Toxicol Methods
January 2025
Department of Pharmacy, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; Department of Gastroenterology, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:
Background: Upadacitinib is a selective Janus kinase (JAK) 1 inhibitor approved by the Food and Drug Administration for the treatment of moderate-to-severe inflammatory bowel disease (IBD). We aimed to establish and validate a method for determining Upadacitinib in patients with IBD by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method.
Methods: The mobile phase was 0.
Simulation of the performance of pillar array columns using the pore-throat ratio as efficiency descriptor.
J Chromatogr A
January 2025
Institute for Bioengineering, School of Engineering, The University of Edinburgh, Edinburgh, EH9 3BF, United Kingdom.
Traditional packed beds in chromatography suffer from increased band broadening due to the random nature of packing, leading non-ideal fluid flow and channeling. To address these challenges, pillar array columns have been developed, offering improved performance over random packing thanks to their homogenous fluid profiles. The study aims to i) evaluate fluid dynamics and chromatographic performance across different PAC morphologies, ii) establish the influence of column morphology on performance, and iii) assess the correlation between chromatographic performance and hydrodynamic parameters.
View Article and Find Full Text PDFBiocementation beyond the Petri dish, scaling up to 900 L batches and a meter-scale column.
Sci Rep
January 2025
Environmental Biotechnology, Institute of Microbiology, Department of Environment, Construction and Design, University of Applied Sciences and Arts of Southern Switzerland (SUPSI), 3 Medusoil SA, EPFL Innovation Park Building A, Manno, Switzerland.
Microbial-induced calcite precipitation (MICP), which leverages ureolytic microorganisms, has received significant attention during the past decade as a promising method for sustainable building and geoenvironmental applications. However, transitioning from lab-scale experimentation to volumes suitable for practical use poses challenges. This study addresses these obstacles by screening and analyzing over 50 strains sourced from (i) a natural environment in the canton of Ticino in Switzerland; (ii) microorganism banks; and (iii) an industry-scale bioreactor.
View Article and Find Full Text PDFSymbolic regression for strength prediction of eccentrically loaded concrete-filled steel tubular columns.
Sci Rep
January 2025
Department of Structural Engineering, Mansoura University, PO BOX 35516, Mansoura, Egypt.
Concrete-filled steel tube (CFST) columns are widely employed in high-rise buildings, long-span bridges, and seismic-resistant structures due to their superior load-bearing capacity, structural efficiency, and resilience under extreme loading conditions. This study uses symbolic regression with structural design code provisions to predict the eccentric strength of concrete filled-steel tubular columns with circular shape (CCFST) and rectangular shape (RCFST). Previous studies have used two distinct approaches for estimating eccentric strength: explainable models based on theoretical derivations and black-box models derived from machine learning (ML) methods.
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