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Filename: controllers/Detail.php
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Function: _error_handler
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Filename: controllers/Detail.php
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Function: _error_handler
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: helpers/my_audit_helper.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Function: _error_handler
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Filename: controllers/Detail.php
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Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
Filename: helpers/my_audit_helper.php
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Unlabelled: The aim of the study was to investigate the effects of rhTSH stimulation before I treatment in patients with MNG.
Methods: Sources included the Cochrane Library, MEDLINE, EMBASE, and SCOPUS database (all until January 2016). Randomized controlled trials (RCTs) that assessed the efficacy of rhTSH-stimulated I treatment compared to placebo or I treatment alone were collected. Two authors performed the data extraction independently.
Results: Six RCTs involving 294 patients with MNG were included in this review. Altogether 168 patients were randomized to rhTSH-stimulated I therapy, and 126 to either placebo and I or I alone. rhTSH-stimulated I vs placebo and I or I alone for MNG showed no statistically significant difference in quality of life and all-cause mortality. rhTSH- (at a dose of 0.03 mg and above) stimulated I treatment for MNG showed significant benefits in thyroid volume reduction. I treatment with rhTSH stimulation at high doses (0.03 mg, 0.1 mg, 0.3 mg and 0.45 mg) for MNG caused significantly higher adverse effects and hypothyroidism.
Conclusions: The overall results indicated that using rhTSH at high doses of 0.03-0.45 mg before I therapy resulted in a greater TVR than I therapy alone for patients with non-toxic MNG. However, an increased incidence of adverse effects and hypothyroidism was observed in patients receiving high-dose of rhTSH pretreatment than in patients who received low-dose rhTSH pretreatment. Therefore, a dose of 0.03 mg rhTSH pretreatment before I therapy may be more potent than I alone in treating patients with non-toxic MNG who either had a contraindication for or declined surgery.
Download full-text PDF |
Source |
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http://dx.doi.org/10.3413/Nukmed-0808-16-03 | DOI Listing |
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