Ibopamine was administered in a dose of 100 mg every 8 hours for three days to 18 hospitalised heart patients of NYHA class I and II. ECHO examination, polygraphic examination, rheographic examination and carotid CW Doppler were carried out under basal conditions and at the end of treatment. B.P. did not show significant changes whereas H.R. showed a slight tendency to rise. PEPc fell significantly whereas LVETw did not change, with a parallel reduction in PEP/LVET. ECHO examination did not reveal any reduction in diameters, an increase in Vcfm and a reduction in Ses. The Ses/Vs and P/V contractility indices increased to some extent. Irrelevant changes were observed in peripheral circulation evaluated with rheography, and cerebral circulation evaluated with CW Doppler. On the basis of these results it can be concluded that ibopamine is in a position to determine an improvement in ventricular performance during heart failure and that, allowing for its sympathergic effects, it is the treatment of choice in bradykinetic decompensation.
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