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Mace Poisoning: Accidental Toxic Ingestion in a Child Leading to a Reversible Coma.
Cureus
December 2024
Psychology Department, Ministry of Defence, Riyadh, SAU.
Nutmeg and mace are commonly known for their medicinal and culinary properties. The chemical compounds found in nutmeg and mace, notably myristicin, elemicin, and safrole, have been implicated in the psychoactive and anticholinergic effects that are the result of acute toxicity. Cases of mace toxicity are not as commonly reported as nutmeg toxicity.
View Article and Find Full Text PDFEffects of psychoplastogens on blood levels of brain-derived neurotrophic factor (BDNF) in humans: a systematic review and meta-analysis.
Mol Psychiatry
February 2025
Molecular Psychiatry Lab, Department of Medicine, University of Fribourg, Fribourg, Switzerland.
Article Synopsis
- A meta-analysis was conducted to evaluate whether psychoplastogens like ketamine and psychedelics increase peripheral BDNF levels in humans, which have been suggested as biomarkers for neuroplasticity.
- The analysis included data from 29 studies and found no significant evidence that these substances elevate peripheral BDNF levels, regardless of various factors such as drug type, dosage, or participant characteristics.
- The findings imply that peripheral BDNF may not be a reliable marker for assessing neuroplasticity changes in humans after psychoplastogen administration, highlighting potential discrepancies between preclinical and human studies.
Datura stramonium seed ingestion leading to unintentional poisoning in a 3-year-old Ethiopian toddler: case report.
Int J Emerg Med
October 2024
Department of Paediatrics and Child Health, College of Health science, Arba Minch University, Arba Minch, Ethiopia.
Introduction: Datura stramonium poisoning, resulting from the ingestion of seeds, leaves, or flowers of Datura stramonium, is a severe condition with significant risks, particularly for young children. Most documented cases of Datura stramonium poisoning in the literature involve teenagers who intentionally ingest the plant to induce hallucinogenic and euphoric experiences. This report presents a rare instance of unintentional Datura stramonium poisoning in a 3year-old Ethiopian toddler.
View Article and Find Full Text PDFA review on abuse-deterrent formulations: formulation technology and regulatory stands in approval process.
Pharm Dev Technol
October 2024
Department of Pharmaceutics, B. K. Mody Government Pharmacy College, Rajkot, India.
Drug abuse has become a global health problem over the past few years. Opioid abuse increased with an increase in the prescription of opioids for pain management. Many other classes of drugs are also abused and misused like anti-depressants, stimulants, hallucinogens, anti-psychotic, and anticholinergic drugs.
View Article and Find Full Text PDFOpposite Contractile Effects of Amphetamine-Related Hallucinogenic Drugs in the Isolated Human Atrium.
Int J Mol Sci
August 2024
Institute for Pharmacology and Toxicology, Medical Faculty, Martin Luther University Halle-Wittenberg, 06097 Halle, Germany.
The present study examined three hallucinogenic amphetamine derivatives, namely, 2,5-dimethoxy-4-iodoamphetamine (DOI) as well as 2,5-dimethoxy-4-methylamphetamine (DOM) and 4-methylmethcathinone (mephedrone). The objective of this study was to test the hypothesis that DOI, DOM, and mephedrone would increase the contractile force in isolated human atrial preparations in a manner similar to amphetamine. To this end, we measured contractile force under isometric conditions in electrically stimulated (1 Hz) human atrial preparations obtained during open surgery.
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