Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/TP.0000000000001340 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Anemia and Mineral Bone Disorder in Kidney Disease Patients: The Role of FGF-23 and Other Related Factors.
Int J Mol Sci
November 2024
Department of Health Sciences, "Magna Graecia" University, I88100 Catanzaro, Italy.
Anemia and mineral and bone disorder (MBD) are significant complications of chronic kidney disease (CKD). The erythropoietin (Epo) pathway plays a key role in both of these processes in CKD. Another molecule that plays an important role in CKD-MBD is fibroblast growth factor (FGF)-23, whose main role is to maintain serum phosphate levels in the normal range, acting via its co-receptor Klotho; however, its activity may also be related to anemia and inflammation.
View Article and Find Full Text PDFInterleukin-6 as a prognostic marker in acute kidney injury and its klotho-dependent regulation.
Nefrologia (Engl Ed)
December 2024
Laboratorio Traslacional Cardiorrenal, Instituto de Investigación Imas12, Hospital Universitario 12 de Octubre, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares CIBER-CV, Hospital Universitario 12 de Octubre, Madrid, Spain; Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, Spain. Electronic address:
Background And Objective: In acute kidney injury (AKI), a strong inflammatory component is activated in response to the renal damage, and one of the main mediators behind this process is the pro-inflammatory interleukin 6 or IL-6. Beside to this phenomenon, there are also alterations in different components of mineral metabolism, such as those dependent on fibroblast growth factor (FGF)23 and the anti-ageing cofactor klotho. The aim of this work was to explore the association between renal function and systemic levels of IL-6, as well as FGF23 and klotho in the early stages of AKI, analysing the predictive capacity of IL-6 in early mortality associated with AKI.
View Article and Find Full Text PDFArticle Synopsis
- Cardiovascular diseases are the leading cause of illness and death in chronic kidney disease patients, with a study analyzing the impact of coronary artery calcifications (CAC) and cardiovascular biomarkers on major adverse cardiovascular events and deaths.
- The study involved 425 non-dialysis CKD patients who underwent scans for CAC scoring and measurement of various cardiovascular risk biomarkers, with follow-up lasting an average of about 3.6 years.
- Findings indicate that high CAC levels significantly increase the risk of major adverse cardiovascular events, especially when combined with certain inflammatory and metabolic conditions, suggesting that managing inflammation and improving mineral metabolism could be key strategies for reducing cardiovascular risk in these patients.
Phosphorous metabolism and manipulation in chronic kidney disease.
Nephrology (Carlton)
December 2024
Service of Nephrology, Ospedale Regionale di Lugano, Ospedale Civico, Ente Ospedaliero Cantonale, Lugano, Switzerland.
Chronic kidney disease-mineral bone disorder (CKD-MBD) is a syndrome commonly observed in subjects with impaired renal function. Phosphate metabolism has been implicated in the pathogenesis of CKD-MBD and according to the phosphorocentric hypothesis may be the key player in the pathogenesis of these abnormalities. As phosphorous is an essential component for life, absorption from the bowel, accumulation and release from the bones, and elimination through the kidneys are all homeostatic mechanisms that maintain phosphate balance through very sophisticated feedback mechanisms, which comprise as main actors: vitamin D (VD), parathyroid hormone (PTH), calciproteins particles (CPPs), fibroblast growth factor-23 (FGF-23) and other phosphatonins and klotho.
View Article and Find Full Text PDFHypoxia Activates FGF-23-ERK/MAPK Signaling Pathway in Ischemia-Reperfusion-Induced Acute Kidney Injury.
Kidney Blood Press Res
November 2024
Shengli Clinical Medical College, Fujian Medical University, Fuzhou, China.
Article Synopsis
- The study investigates the relationship between hypoxia and fibroblast growth factor-23 (FGF-23) in the context of acute kidney injury (AKI) caused by ischemia-reperfusion (I/R).
- Using an I/R animal model and human kidney cells, researchers measured various cytokines and biomarkers to examine the impact of hypoxia on kidney health.
- Findings indicate that FGF-23 plays a significant role in AKI, with hypoxia inducing cell apoptosis and inflammatory responses, regulated through the ERK/MAPK signaling pathway.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!