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Intrahepatic CD161CD8+T Cell Recruitment Has a Pathogenetic Potential in Chronic HBV Infection.
Immun Inflamm Dis
January 2025
Department of Clinical Laboratory, the Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Backgrounds And Aims: CD8+T cells are crucially associated with the fight against hepatitis B virus (HBV) infection. CD161 has been shown to express remarkably on HCV-specific CD8+T cells. However, the accurate function of CD161+CD8+T cells in HBV immunity or pathogenesis remains undetermined.
View Article and Find Full Text PDFExogenous Melatonin Boosts Heat Tolerance in via Modulation.
Plants (Basel)
December 2024
College of Architectural Engineering, Shenzhen Polytechnic University, Shenzhen 518055, China.
is one the most commonly cultivated ornamental plant of economic importance and faces major challenges under heat stress. Melatonin has been widely shown to regulate plant stress response; however, the exact mechanism involved in heat stress in has yet to be determined. Here, we observed that in vitro plantlets supplemented with melatonin in the culture medium exhibited higher chlorophyll content, relative ion leakage, and fresh weight after 12 d of high-temperature treatment; the optimal concentration was established at 5 mg/L.
View Article and Find Full Text PDFDisrupted mitochondrial morphology and function exacerbate inflammation in elderly-onset ulcerative colitis.
Immun Ageing
January 2025
Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background: The characteristics of ulcerative colitis (UC) in the elderly are quite different from the young population. Mitochondrial injury is a key mechanism regulating both aging and inflammation. This study aims to reveal the role of mitochondrial damage in the pathogenesis of adult- and elderly-onset UC.
View Article and Find Full Text PDFMicrobial community structure and causal analysis in sediments of shallow eutrophic freshwater lakes under heavy metal compound pollution.
J Hazard Mater
January 2025
The National Key Laboratory of Water Disaster Prevention, Hohai University, Nanjing 210098, China; College of Hydrology and Water Resources, Hohai University, Nanjing 210098, China. Electronic address:
Heavy metals, due to their toxicity, persistence, and non-biodegradability, have become some of the most severe environmental pollutants globally. Their accumulation in lake sediments can significantly impact aquatic ecosystems' biogeochemical cycles by altering the ecological dynamics of microbial communities. To further elucidate the mechanisms underlying microbial responses to complex heavy metal pollution in lake sediments, sediment samples were collected from Nan Yi Lake, and their physicochemical properties and microbial composition were systematically analyzed.
View Article and Find Full Text PDFSRPKs Homolog Dsk1 Regulates Homologous Recombination Repair in Schizosaccharomyces pombe.
Genes Cells
January 2025
Jiangsu Key Laboratory for Pathogens and Ecosystems, College of Life Sciences, Nanjing Normal University, Nanjing, China.
Serine-arginine protein kinases (SRPKs) play important roles in diverse biological processes such as alternative splicing and cell cycle. However, the functions of SRPKs in DNA damage response remain unclear. Here we characterized the function of SRPKs homolog Dsk1 in regulating DNA repair in the fission yeast Schizosaccharomyces pombe.
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