In this issue of Neuron, Lee et al. (2016) assessed the brain-wide effects of stimulating the direct and indirect pathway by optogenetic activation of D1 and D2 striatal neurons. This work demonstrates the exquisite power of combining cell-type-specific perturbation methods with focal and whole-brain measurements of brain activity.
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| http://dx.doi.org/10.1016/j.neuron.2016.07.012 | DOI Listing |
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Grandparental childcare and subjective well-being: The role of activities and reasons for care.
Soc Sci Med
January 2025
Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, 355a, London, WC1E 7HB, UK.
Despite extensive research on the impact of grandchild care on grandparents' well-being, no studies have examined the frequency of activities that grandparents engage in with their grandchildren or the reasons for care using nationally representative data. We address this gap using waves 8 (2016/2017) and 9 (2018/19) of the English Longitudinal Study of Ageing, a nationally representative study of English older adults. We employ hybrid regression models to distinguish between within- and between-individual effects on grandparents' subjective wellbeing, as captured by quality of life and depressive symptoms.
View Article and Find Full Text PDFConsequences of COVID-19 for geriatric patients during a pandemic.
Sci Rep
January 2025
Department of Geriatric Medicine, University Duisburg-Essen, Essen, Germany.
To investigate the outcomes of geriatric COVID-19 patients in a German academic setting during the pandemic. This study included 468 consecutive geriatric patients (≥ 70 years) who tested positive for SARS-CoV-2 and were treated at the University of Duisburg-Essen from 2/2020 to 3/2021. 74 patients were transferred to a geriatric hospital and a 12-month follow-up (prospective study) was performed in 51 patients.
View Article and Find Full Text PDFEffect of early rehabilitation on hospital stay and postoperative complications in elderly hip fracture patients: a prospective cohort study.
J Orthop Surg Res
January 2025
Department of Emergency Medicine Center, The First Affiliated Hospital, Hengyang Medical School, University of South China, No.69 Chuanshan Road, Shigu District, 421001, Hengyang City, Hunan Province, China.
Background: Hip fractures in the elderly are a major global public health concern, with incidence projected to rise as populations age. Rehabilitation is critical to recovery after hip fracture surgery, but the ideal timing for initiation remains uncertain. While early rehabilitation, within 48 h post-surgery, is associated with better outcomes, its specific impact on hospital stay duration and postoperative complications is not yet conclusively established.
View Article and Find Full Text PDFIdentifying Patients at Risk for a Facility Discharge Following Elective Total Joint Arthroplasty Using Preoperative Clinical Findings and Patient-Reported Outcome Scores.
J Arthroplasty
January 2025
Hartford Healthcare Bone and Joint Institute, 32 Seymour Street, Hartford, CT 06106; Orthopaedic Associates of Hartford, 31 Seymour Street, Hartford, CT 06106.
Introduction: Facility discharges following an elective, primary, total joint arthroplasty are infrequent, but are associated with poor outcomes and significant cost. Therefore, investigating ways to identify patients most likely to be discharged to a facility could improve patient care, reduce costs, and potentially lead to strategies to mitigate these risks.
Methods: A total of 3,198 patients who underwent a total hip or knee arthroplasty between June 2021 and June 2023 were included in this study.
Effectiveness of rehabilitation in hospitalized hemodialysis patients as compared with rehabilitation in hospitalized patients not on hemodialysis: a retrospective cohort study.
J Nephrol
January 2025
Dialysis Division, Kaikoukai Healthcare Group, Nagoya, Aichi, Japan.
Background: The effectiveness of rehabilitation aimed at improving the activities of daily living and physical functions may differ between hospitalized patients undergoing hemodialysis (HD) and not undergoing HD (non-HD). The aim of the present study was to compare the outcomes of rehabilitation between hospitalized HD and non-HD patients.
Methods: This was a retrospective cohort study of inpatients who underwent rehabilitation.
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