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Drug Development.
Alzheimers Dement
December 2024
University of Kentucky Sanders-Brown Center on Aging, Lexington, KY, USA.
Background: The presence of multiple comorbid pathologic features in late-onset dementia has been well documented across cohort studies that incorporate autopsy evaluation. It is likely that such mixed pathology potentially confounds the results of interventional trials that are designed to target a solitary pathophysiologic mechanism in Alzheimer's disease and related dementias (ADRD).
Method: The UK ADRC autopsy database was screened for participants who had previously engaged in therapeutic interventional trials for Alzheimer's disease, vascular cognitive impairment, dementia, and/or ADRD prevention trials from 2005 to the present.
Dementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
NYU Grossman School of Medicine, New York, NY, USA.
Background: In the United States, Black people represent 12% of the total US population and account for 19.3% of dementia cases. Social determinants of health (SDOH) and vascular comorbidities contribute to Black/African Americans having a higher risk of Alzheimer's disease and related dementias (ADRD).
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Puerto Rico Department of Health, San Juan, Puerto Rico, Puerto Rico.
Background: Alzheimer's Disease (AD) is the fourth leading cause of death in Puerto Rico (PR), with an estimated prevalence of 14%. Caregivers are an essential part in the management and care of people with AD. Providing care for a person with Alzheimer can change over time and can become a challenge for the caregivers.
View Article and Find Full Text PDFDementia Care Research and Psychosocial Factors.
Alzheimers Dement
December 2024
Inserm U1094, IRD UMR270, Univ. Limoges, CHU Limoges, EpiMaCT, Limoges, France.
Background: In sub-Saharan Africa (SSA), the number of people living with dementia is expected to double every 20 years, from 2.7 to 7.6 million.
View Article and Find Full Text PDFDementia Care Practice.
Alzheimers Dement
December 2024
University of Waterloo, Waterloo, ON, Canada.
Background: The use of potentially inappropriate medications (PIMs) in older adults with dementia and/or Mild Cognitive Impairment (MCI) has been associated with increased adverse events, drug-related problems (DRPs), prolonged hospitalization, risk of falls, and increased length of stay. This study aimed to identify which explicit tool, Beers criteria 2023 or Screening Tool of Older Persons Potentially Inappropriate Prescriptions (STOPP) 2023, identifies more PIM use among older adults with MCI or dementia.
Methods: A cross-sectional study was conducted at a Multispecialty Interprofessional Team-based (MINT) memory clinic.
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