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Association of Organophosphorus Pesticide and Glyphosate Exposure with Nasal Flora and Total IgE in Solar Greenhouse Workers: A Unique Farmer Group.
Environ Pollut
January 2025
Beijing Institute of Occupational Disease Prevention and Control, Beijing 100093, China. Electronic address:
Studies have shown that the presence of allergens, including insecticides, significantly increases the risk of occupational allergic diseases among solar greenhouse workers. However, no studies have yet investigated the relationship between organophosphorus pesticide use by greenhouse workers and allergic diseases, and the role of the flora in this context remains unclear. Therefore, this study aimed to investigate the relationship between combined exposure to organophosphorus pesticides (OPs) and Glyphosate (GLY) and changes in total immunoglobulin E (IgE) levels, as well as to analyze the role of nasal flora in allergic status.
View Article and Find Full Text PDFThe Significant Role of Atopic Skin Diathesis in Prurigo Nodularis.
Sisli Etfal Hastan Tip Bul
December 2024
Department of Dermatology and Venereology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
Objectives: Atopic skin plays a significant etiological role in the development of prurigo nodularis (PN). In addition to atopic dermatitis (AD), atopic skin diathesis without eczema can also contribute to the development of PN due to its association with itching. This study aims to evaluate PN in terms of AD/atopic skin diathesis, associated comorbidities, and clinical findings.
View Article and Find Full Text PDFFirst-in-human study on tolerability, pharmacokinetics and pharmacodynamics of single and multiple escalating doses of XKH001, a recombinant humanized monoclonal antibody against IL-25 in healthy Chinese volunteers.
Expert Opin Investig Drugs
January 2025
Department of Pediatric Respiratory, Children's Medical Center, The First Hospital of Jilin University, Jilin, China.
Background: XKH001 is a recombinant humanized IgG1 monoclonal antibody against IL-25 for the treatment of type 2 inflammatory diseases. This study aimed to evaluate the tolerability, pharmacokinetics, and pharmacodynamics of XKH001 in humans for the first time.
Research Design And Methods: This clinical investigation adopted a randomized, double-blind, and placebo-controlled single ascending dose (SAD) and multiple ascending dose (MAD) design.
Multi-biofluid metabolomics analysis of allergic respiratory rhinitis and asthma in early childhood.
World Allergy Organ J
January 2025
Clinical Metabolomics Core Laboratory, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Background: Childhood rhinitis and asthma are allergic respiratory diseases triggered by common allergens, but they affect different parts of the respiratory system, leading to distinct symptoms. However, a comprehensive multi-biofluid metabolomics-based approach to uncover valuable insights into childhood allergies and allergen sensitization remains unaddressed.
Methods: Seventy-six children, comprising 26 with rhinitis, 26 with asthma, and 24 healthy controls, were enrolled.
Development of a Buckwheat Allergy in a Child During Food Protein-Induced Enterocolitis Syndrome Due to Hen's Egg: A Case Report.
Cureus
December 2024
Department of Pediatrics, IMS Group, IMS Memorial Hospital, Tokyo, JPN.
Food protein-induced enterocolitis syndrome (FPIES) is a non-immunoglobulin E (IgE)-mediated food allergy. IgE sensitization to the causative food is often not observed, and the rate of sensitization to other common foods is not exceptionally high. This report discusses the case of a boy being followed up for FPIES due to egg yolk, who developed a buckwheat allergy during the disease.
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