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Why Bax detection in >1400 publications might be flawed.
Cell Death Dis
December 2024
University of Stuttgart, Institute of Cell Biology and Immunology, Stuttgart, Germany.
BCL-2 and BOK regulate apoptosis by interaction of their C-terminal transmembrane domains.
EMBO Rep
September 2024
Robert Bosch Center for Tumor Diseases, Stuttgart, Germany.
The Bcl-2 family controls apoptosis by direct interactions of pro- and anti-apoptotic proteins. The principle mechanism is binding of the BH3 domain of pro-apoptotic proteins to the hydrophobic groove of anti-apoptotic siblings, which is therapeutically exploited by approved BH3-mimetic anti-cancer drugs. Evidence suggests that also the transmembrane domain (TMD) of Bcl-2 proteins can mediate Bcl-2 interactions.
View Article and Find Full Text PDFTRAIL-induced apoptosis and proteasomal activity - Mechanisms, signalling and interplay.
Biochim Biophys Acta Mol Cell Res
April 2024
University of Stuttgart, Institute of Cell Biology and Immunology, Stuttgart 70569, Germany; University of Stuttgart, Stuttgart Research Center Systems Biology, Stuttgart 70569, Germany. Electronic address:
Programmed cell death, in particular apoptosis, is essential during development and tissue homeostasis, and also is the primary strategy to induce cancer cell death by cytotoxic therapies. Precision therapeutics targeting TRAIL death receptors are being evaluated as novel anti-cancer agents, while in parallel highly specific proteasome inhibitors have gained approval as drugs. TRAIL-dependent signalling and proteasomal control of cellular proteostasis are intricate processes, and their interplay can be exploited to enhance therapeutic killing of cancer cells in combination therapies.
View Article and Find Full Text PDFFrequent Follow-Up of Delisted Liver Transplant Candidates Is Necessary: An Observational Study about Characteristics and Outcomes of Delisted Liver Transplant Candidates.
J Clin Med
September 2023
Department of General-, Visceral- and Transplant Surgery, LMU University Hospital, 81377 Munich, Germany.
This observational study focuses on the characteristics and survival of patients taken off of the liver transplant waiting list. Assessment of post-delisting survival and a frequent follow-up of patients after delisting are important keys to improve the survival rate of patients with liver failure after being delisted. Within this study, delisted liver transplant candidates were divided into the following groups: (1) "too good" (54%) or (2) "too sick" (22%) for transplantation, (3) adherence issues (12%) or (4) therapy goal changed (11%).
View Article and Find Full Text PDFApoptotic cell death in disease-Current understanding of the NCCD 2023.
Cell Death Differ
May 2023
Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions.
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