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Rethinking clinical guidance: the imperative for evidence-based and inclusive practices in managing gender dysphoria in youth.
Evid Based Nurs
January 2025
Nursing, University of Nevada Reno, Reno, Nevada, USA.
Influence of androgen receptor on bone health in transgender adults: insights from the COMET study.
J Endocrinol Invest
January 2025
Regional Reference Center for Gender Incongruence (CRRIG) of the Veneto Region, University Hospital of Padova, Padua, Italy.
Purpose: Previous studies show that transgender and gender-diverse (TGD) individuals, especially those assigned male at birth (AMAB), often have low bone mineral density (BMD) before beginning gender-affirming hormone therapy (GAHT). The reasons for this are not fully understood, and the potential role of androgen receptor (AR) polymorphisms - known to affect bone density in the general population - has not been explored. This study aims to assess the impact of AR polymorphisms on bone health in the TGD population.
View Article and Find Full Text PDFA sterilization method for human decellularized vaginal matrices.
Sci Rep
December 2024
Department of Medical Microbiology and Infection Prevention, Amsterdam UMC - Location AMC, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.
Vaginal reconstruction is necessary for various congenital and acquired conditions, including vaginal aplasia, trauma, tumors, and gender incongruency. Current surgical and non-surgical treatments often result in significant complications. Decellularized vaginal matrices (DVMs) from human tissue offer a promising alternative, but require effective sterilization to ensure safety and functionality.
View Article and Find Full Text PDFPromoting trans patient autonomy in surgical preparation for phalloplasty and metoidioplasty: results from a community-based cross-sectional survey and implications for preoperative assessments.
BMC Med Ethics
December 2024
School of Public Health and Social Policy, Faculty of Human and Social Development, University of Victoria, Victoria, BC, Canada.
Background: Some transgender and nonbinary people undergo phalloplasty and/or metoidioplasty as part of their medical transition process. Across surgical disciplines, a variety of resources are used to assist patients who are preparing for surgeries, including educational materials, workshops, peer support, and lifestyle changes. For gender-affirming surgeries, patients undergoing assessments to discern whether they are ready to undergo the surgery, and to assist them in achieving preparedness when needed.
View Article and Find Full Text PDFPrevalence of Intersex/Differences in Sex Development and Primary Gonadal Insufficiency in a Pediatric Transgender Population.
Transgend Health
December 2024
University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.
Purpose: This study aims to assess the prevalence of intersex variations/differences in sex development (I/DSDs), associated adrenal conditions, and primary gonadal insufficiency in children with gender dysphoria.
Methods: We performed a comprehensive review of the medical records for individuals who carried the diagnostic codes for gender dysphoria in addition to intersex and/or other conditions associated with sex steroid variations among patients evaluated by pediatric endocrinologists from 2013 to 2022.
Results: We found that 9 of 612 (1.
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