Bats are notorious reservoirs of genetically-diverse and high-profile pathogens, and are playing crucial roles in the emergence and re-emergence of viruses, both in human and in animals. In this report, we identified and characterized previously unknown and diverse genetic clusters of bat coronaviruses in the Atlantic Forest Biome, Brazil. These results highlight the virus richness of bats and their possible roles in the public health.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106056 | PMC |
http://dx.doi.org/10.1016/j.meegid.2016.07.034 | DOI Listing |
Commun Biol
January 2025
Dept. Electrical Engineering and Computer Science, Florida Atlantic University, 777 Glades Road, Boca Raton, FL, 33431, USA.
Predicting novel mutations has long-lasting impacts on life science research. Traditionally, this problem is addressed through wet-lab experiments, which are often expensive and time consuming. The recent advancement in neural language models has provided stunning results in modeling and deciphering sequences.
View Article and Find Full Text PDFOpen Forum Infect Dis
January 2025
Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Background: Household transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may play a key role in times of increased infection, particularly among children. We aimed to determine the prevalence of SARS-CoV-2 antibodies and identify risk factors associated with SARS-CoV-2 antibody positivity in children.
Methods: Unvaccinated children aged 18 months to 11 years between August 2022 and June 2023 underwent oral fluid testing for SARS-CoV-2 antibodies.
J Exp Med
December 2024
Section of Paediatric Infectious Disease, Department of Infectious Disease, Faculty of Medicine, Imperial College London, London, UK.
Multisystem inflammatory syndrome in children (MIS-C) is a rare condition following SARS-CoV-2 infection associated with intestinal manifestations. Genetic predisposition, including inborn errors of the OAS-RNAseL pathway, has been reported. We sequenced 154 MIS-C patients and utilized a novel statistical framework of gene burden analysis, "burdenMC," which identified an enrichment for rare predicted-deleterious variants in BTNL8 (OR = 4.
View Article and Find Full Text PDFInt J Geriatr Psychiatry
November 2024
Global Brain Health Institute, Trinity College, Dublin, Ireland.
J Hazard Mater
January 2025
CORAL, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
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