A convergent approach to side-chain homologated derivatives of 1α,25-dihydroxyergocalciferol.

J Steroid Biochem Mol Biol

Department of Organic Chemistry, Laboratorio "Ignacio Ribas", University of Santiago de Compostela, Avda Ciencias s/n, 15782 Santiago de Compostela, Spain. Electronic address:

Published: October 2017

As part of our program on search for vitamin D analogs with selective biological properties, such as low or negligible calcemic action, we describe here an efficient and versatile synthetic approach to derivatives of 1α,25-dihydroxyvitamin D with homologated side-chains and substitution at C24 for biological evaluation.

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http://dx.doi.org/10.1016/j.jsbmb.2016.07.015DOI Listing

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