Validation of the American Society for Reproductive Medicine guidelines/recommendations in white European men presenting for couple's infertility.

Fertil Steril

Division of Experimental Oncology/Unit of Urology, Urological Research Institute, Istituto di Ricerca e Cura a Carattere Scientifico Ospedale San Raffaele, Milan, Italy; Università Vita-Salute San Raffaele, Milan, Italy. Electronic address:

Published: October 2016

Objective: To retrospectively validate the American Society for Reproductive Medicine (ASRM) guidelines/recommendations concerning endocrine evaluation in a cohort of white European men presenting for couple's infertility.

Design: Retrospective study.

Setting: Academic reproductive medicine outpatient clinic.

Patient(s): Cohort of 1,056 consecutive infertile men (noninterracial infertile couples).

Intervention(s): Testicular volume was assessed with a Prader orchidometer. Serum hormones were measured (8-10 a.m.) in all cases. Hypogonadism was defined as total T < 3 ng/mL, according to the Endocrine Society definition. Semen analysis values were assessed based on the 2010 World Health Organisation reference criteria.

Main Outcome Measure(s): ASRM indications for endocrine assessment in infertile men (sperm concentration <10 million/mL, impaired sexual function, and other clinical findings suggesting a specific endocrinopathy) were used to predict hypogonadism in our cohort. Moreover, a clinically user-friendly three-item nomogram was developed to predict hypogonadism and was compared to the ASRM guidelines assessment.

Result(s): Biochemical hypogonadism was diagnosed in 156 (14.8%) men. Overall, 669 (63.4%) patients would have necessitated total T assessment according to the ASRM criteria; of these, only 119 (17.8%) were actually hypogonadal according to the Endocrine Society classification criteria. Conversely, 37 (23.7%) out of 156 patients with biochemical hypogonadism would have been overlooked. The overall predictive accuracy, sensitivity, and specificity of the ASRM guidelines was 58%, 76%, and 39%, respectively. Our nomogram was not reliable enough to predict hypogonadism, despite demonstrating a significantly higher predictive accuracy (68%) than the ASRM guidelines.

Conclusion(s): The current findings show that the ASRM guidelines/recommendations for male infertility workup may not be suitable for application in white European infertile men.

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Source
http://dx.doi.org/10.1016/j.fertnstert.2016.06.044DOI Listing

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