AI Article Synopsis
- - The study aims to analyze the genetic diversity of specific cytochrome and sulfotransferase polymorphisms in six North African populations, noting a lack of existing data on these groups.
- - Researchers examined eight genetic polymorphisms in 556 individuals from Morocco, Algeria, Tunisia, and Libya, revealing significant differences in allele frequencies compared to European populations.
- - The findings indicate that North African populations are genetically diverse and heterogeneous, with a notable sub-Saharan African influence linked to markers that may affect prostate cancer risk and drug metabolism.
Article Abstract
Aim: To describe the diversity of four cytochrome and four sulfotransferase polymorphisms in six north African samples. Scarce data have been compiled for these samples despite the rich genetic background of north African populations.
Materials & Methods: CYP3A4*1B, CYP3A4*17, CYP3A4*3, CYP3A5*3, SULT1A1*2, SULT1A2*2, SULT1A2*3 and SULT1E1*2 polymorphisms were explored in 556 individuals from Morocco, Algeria, Tunisia and Libya.
Results: Allele frequencies in our samples largely exceeded the variation ranges described for European populations, especially for CYP3A4*1B, SULT1A1*2 and SULT1A2*3.
Conclusion: North African populations are heterogeneous, genetically diverse and show a considerable sub-Saharan African contribution for markers associated with increased risk of prostate cancer and with differential drug metabolism.
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| http://dx.doi.org/10.2217/pgs-2016-0016 | DOI Listing |
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