Hypomagnesemia can be caused by a wide range of diseases (e.g. gastrointestinal disorders, kidney diseases or endocrine disorders), but it can also be a side effect of several drugs. It can be asymptomatic or cause many different clinical symptoms, and the clinical manifestations mainly depend on the rate of development rather than the actual serum magnesium concentration. We here present a 40-year-old female patient with Torsade de pointes ventricular tachycardia and cardiac arrest caused by severe hypomagnesemia as an adverse effect of the proton pump inhibitor omeprazole.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962887 | PMC |
| http://dx.doi.org/10.1093/omcr/omw062 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mitigating the Risk of QTc Prolongation When Using Haloperidol for Acute Treatment of Cannabinoid Hyperemesis Syndrome in Adolescents and Young Adults.
J Clin Med
December 2024
Department of Pharmacy, CHOC Children's Hospital, Orange, CA 92868, USA.
: Cannabinoid Hyperemesis Syndrome (CHS), associated with long-term cannabinoid use, has been increasingly observed in emergency room visits as more states in the U.S. have legislatively permitted medical and recreational marijuana use.
View Article and Find Full Text PDFProton pump inhibitor-induced hypomagnesemia, a rare cause of reversible delirium: A case report with literature review.
Medicine (Baltimore)
October 2024
Department of Endocrinology, Tianjin Medical University General Hospital, Tianjin, China.
Article Synopsis
- Hypomagnesemia can lead to serious electrolyte imbalances and neurological symptoms, including delirium, which may be linked to the use of proton pump inhibitors (PPIs) like omeprazole.
- A case study of a 74-year-old woman highlighted that despite normal parathyroid hormone levels, she experienced hypomagnesemia and hypocalcemia, leading to delirium and nausea.
- After discontinuing the PPI and administering magnesium, calcium, and potassium supplements, her symptoms improved, emphasizing the need for clinicians to recognize the potential risks of PPIs and monitor magnesium levels.
Seizure and Takotsubo Cardiomyopathy Due to Proton Pump Inhibitor.
J Community Hosp Intern Med Perspect
July 2024
Medstar Health Internal Medicine Residency Program, Baltimore, MD, USA.
Article Synopsis
- Proton Pump Inhibitor (PPI) use has been linked to serious electrolyte imbalances, particularly hypomagnesemia, which can lead to life-threatening conditions.
- An 80-year-old woman presented with generalized weakness and diarrhea, revealing severe electrolyte abnormalities that did not improve until her PPI medication was discontinued.
- Her hospital stay was complicated by a seizure, likely caused by electrolyte-induced changes in neuronal activity, and she also suffered from Takotsubo cardiomyopathy due to reduced heart function related to prolonged PPI use.
Article Synopsis
- - Proton pump inhibitors (PPIs) are commonly used medications but can cause serious electrolyte imbalances, particularly low magnesium (hypomagnesaemia), which can lead to additional issues like low calcium (hypocalcaemia) and low potassium (hypokalaemia).
- - Long-term PPI use disrupts intestinal pH and interferes with magnesium transport mechanisms, which can lead to increased potassium loss and complications in calcium regulation.
- - These electrolyte imbalances can become severe and resistant to typical supplementation efforts, posing significant health risks for some patients who rely on chronic PPI therapy.
Challenges in the management of patients with HNF1B MODY and multisystem manifestations: the cases of two adolescent boys.
Hormones (Athens)
September 2024
Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, "Aghia Sophia" Children's Hospital, Athens, 11527, Greece.
Introduction: Hepatocyte nuclear factor-1 beta (HNF1B) encodes a homeodomain-containing transcription factor, which is expressed early in embryogenesis and is involved in the development of multiple tissues and organs. HNF1B mutations cause complex multisystem disorders, with renal developmental disease and maturity onset diabetes of the young (HNF1B MODY), a rare cause of diabetes mellitus, being representative features.
Methods: We present two adolescent boys from different socioeconomic backgrounds who were diagnosed with genetically confirmed HNF1B MODY following hospitalization for diabetic ketoacidosis in the first case and after diagnostic work-up due to impaired glucose tolerance in the second case.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!