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| http://dx.doi.org/10.3324/haematol.2016.146555 | DOI Listing |
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Comparative effects of metformin and varying intensities of exercise on miR-133a expression in diabetic rats: Insights from machine learning analysis.
Biochem Biophys Rep
December 2024
Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran.
Article Synopsis
- - The study looked at how metformin, high-intensity interval training (HIIT), and moderate-intensity continuous training (MCT) affect miR-133a levels, a microRNA linked to insulin resistance in diabetic rats.
- - Diabetic rats had higher levels of miR-133a, but treatments with HIIT and MCT, especially when combined with metformin, significantly reduced these levels, with the HIIT and metformin combo being the most effective.
- - A predictive model using the CatBoost algorithm was developed to accurately estimate miR-133a levels based on various metabolic factors, suggesting that combining metformin and exercise could lead to personalized diabetes treatment using miR-133a as a biomarker
The role of mir-7-5p in cancer: function, prognosis, diagnosis, and therapeutic implications.
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November 2024
Department of Medical Genetics, Tabriz University of Medical Sciences, Tabriz, Iran.
One of the important and conserved microRNAs (miRNAs), miR-7-5p, is involved in several pathological mechanisms, including cell proliferation, apoptosis, migration, and metastasis. Dysregulation of this miRNA's expression is correlated with multiple diseases, especially cancer. Its role as a tumor suppressor has been demonstrated in various types of cancer, such as colorectal cancer, lung cancer, bladder cancer, breast cancer, and glioblastoma.
View Article and Find Full Text PDFExtracellular vesicle biogenesis of three-dimensional human pluripotent stem cells in a novel Vertical-Wheel bioreactor.
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Department of Chemical and Biomedical Engineering, FAMU-FSU College of Engineering Florida State University Tallahassee Florida USA.
Extracellular vesicles (EVs) secreted by human-induced pluripotent stem cells (hiPSCs) have great potential as cell-free therapies in various diseases, including prevention of blood-brain barrier senescence and stroke. However, there are still challenges in pre-clinical and clinical use of hiPSC-EVs due to the need for large-scale production of a large quantity. Vertical-Wheel bioreactors (VWBRs) have design features that allow the biomanufacturing of hiPSC-EVs using a scalable aggregate or microcarrier-based culture system under low shear stress.
View Article and Find Full Text PDFmiR-145a-5p/SIK1/cAMP-dependent alteration of synaptic structural plasticity drives cognitive impairment induced by coke oven emissions.
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Department of Toxicology, School of Public Health, Qingdao University, Qingdao 266071, China. Electronic address:
Exposure to fine particulate matter (PM) is associated with the neurodegenerative diseases. Coke oven emissions (COEs) in occupational environment are important sources of PM. However, its neurotoxicity is still unclear.
View Article and Find Full Text PDFA lineage-resolved cartography of microRNA promoter activity in C. elegans empowers multidimensional developmental analysis.
Nat Commun
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State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Elucidating the expression of microRNAs in developing single cells is critical for functional discovery. Here, we construct scCAMERA (single-cell cartography of microRNA expression based on reporter assay), utilizing promoter-driven fluorescent reporters in conjunction with imaging and lineage tracing. The cartography delineates the transcriptional activity of 54 conserved microRNAs in lineage-resolved single cells throughout C.
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