AI Article Synopsis
- The Class III phosphoinositide 3-kinase Vps34 is crucial in various cellular processes such as endocytic trafficking and nutrient sensing.
- Recent research has shed light on its structure, regulation, and newly identified cellular functions.
- This review aims to analyze and combine the latest findings with existing models of Vps34 signaling.
Article Abstract
The Class III phosphoinositide 3-kinase Vps34 (vacuolar protein sorting 34) plays important roles in endocytic trafficking, macroautophagy, phagocytosis, cytokinesis and nutrient sensing. Recent studies have provided exciting new insights into the structure and regulation of this lipid kinase, and new cellular functions for Vps34 have emerged. This review critically examines the wealth of new data on this important enzyme, and attempts to integrate these findings with current models of Vps34 signalling.
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| http://dx.doi.org/10.1042/BCJ20160170 | DOI Listing |
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