Background: The presence of six or more café au lait (CAL) spots is a criterion for the diagnosis of neurofibromatosis type 1 (NF-1). Children with multiple CAL spots are often referred to dermatologists for NF-1 screening. The objective of this case series is to characterize a subset of fair-complected children with red or blond hair and multiple feathery CAL spots who did not meet the criteria for NF-1 at the time of their last evaluation.
Methods: We conducted a chart review of eight patients seen in our pediatric dermatology clinic who were previously identified as having multiple CAL spots and no other signs or symptoms of NF-1.
Results: We describe eight patients ages 2 to 9 years old with multiple, irregular CAL spots with feathery borders and no other signs or symptoms of NF-1. Most of these patients had red or blond hair and were fair complected. All patients were evaluated in our pediatric dermatology clinic, some with a geneticist. The number of CAL spots per patient ranged from 5 to 15 (mean 9.4, median 9).
Conclusion: A subset of children, many with fair complexions and red or blond hair, has an increased number of feathery CAL spots and appears unlikely to develop NF-1, although genetic testing was not conducted. It is important to recognize the benign nature of CAL spots in these patients so that appropriate screening and follow-up recommendations may be made.
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http://dx.doi.org/10.1111/pde.12936 | DOI Listing |
J Fungi (Basel)
November 2024
Plan Protection Department, College of Agronomy, Sichuan Agricultural University, Chengdu 611130, China.
Plant Dis
November 2024
Huaihua University, Huaihua, Hunan, China;
Plant Dis
October 2024
Chiang Mai University Faculty of Science, Research Center of Microbial Diversity and Sustainable Utilization, 239, Huay Kaew Road,, Muang District, Chiang Mai, Thailand, 50200;
Plant Dis
August 2024
CREA, Conegliano, TV, Italy;
Plant Dis
July 2024
Guangxi Academy of Agricultural Sciences, Institute of Plant Protection, 174 daxue road, Nanning, Guangxi Province, Nanning, Guangxi, China, 530007;
(L.)Jongkind, distributed in Southeast Asia, is widely planted in southern China for its ornamental and medicinal value. In February 2023, anthracnose symptoms were observed on leaves in Nanning Garden Expo (N22°43', E108°28'), Guangxi, China, causing severe defoliation of infected plants with a foliar disease incidence ranging from 40 to 60% (n = 100) in a 2 ha field.
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