Background: The presence of six or more café au lait (CAL) spots is a criterion for the diagnosis of neurofibromatosis type 1 (NF-1). Children with multiple CAL spots are often referred to dermatologists for NF-1 screening. The objective of this case series is to characterize a subset of fair-complected children with red or blond hair and multiple feathery CAL spots who did not meet the criteria for NF-1 at the time of their last evaluation.

Methods: We conducted a chart review of eight patients seen in our pediatric dermatology clinic who were previously identified as having multiple CAL spots and no other signs or symptoms of NF-1.

Results: We describe eight patients ages 2 to 9 years old with multiple, irregular CAL spots with feathery borders and no other signs or symptoms of NF-1. Most of these patients had red or blond hair and were fair complected. All patients were evaluated in our pediatric dermatology clinic, some with a geneticist. The number of CAL spots per patient ranged from 5 to 15 (mean 9.4, median 9).

Conclusion: A subset of children, many with fair complexions and red or blond hair, has an increased number of feathery CAL spots and appears unlikely to develop NF-1, although genetic testing was not conducted. It is important to recognize the benign nature of CAL spots in these patients so that appropriate screening and follow-up recommendations may be made.

Download full-text PDF

Source
http://dx.doi.org/10.1111/pde.12936DOI Listing

Publication Analysis

Top Keywords

cal spots
32
signs symptoms
12
red blond
12
blond hair
12
spots
9
café lait
8
neurofibromatosis type
8
cal
8
multiple cal
8
feathery cal
8

Similar Publications

Identification and Characterization of Species Associated with Maize in Sichuan, China.

J Fungi (Basel)

November 2024

Plan Protection Department, College of Agronomy, Sichuan Agricultural University, Chengdu 611130, China.

Article Synopsis
  • - The study focuses on identifying the species causing maize anthracnose, primarily characterized by leaf spots, and distinguishes these from other similar pathogens.
  • - Researchers analyzed 99 fungal isolates through morphological identification and gene sequence analysis, identifying 10 different species, with the most dominant being a specific species occurring at a rate of 24.2%.
  • - For the first time, pathogenicity tests confirmed the virulence of several species as causative agents of maize anthracnose, while also identifying one species as an endophytic fungus in healthy maize, highlighting the study's significance for disease management in Sichuan Province.
View Article and Find Full Text PDF
Article Synopsis
  • The text discusses the medicinal benefits of a plant species (Sieb. et Zucc.) Maxim, which aids in dispersing cold, tonifying kidneys and bones, and strengthening muscles.
  • A new leaf disease was detected in June 2023 in Xinning County, China, affecting 50% of the cultivated area, characterized by lesions that started at the tips and spread to yellowish-white spots.
  • Researchers isolated the pathogen from infected leaves through a series of disinfection and incubation steps, identifying eight isolates, with six belonging to a specific genus, and confirming their identities through gene sequencing of five specific regions.
View Article and Find Full Text PDF
Article Synopsis
  • Jackfruit in Thailand has been affected by leaf anthracnose, leading to around 25% disease incidence in a specific plantation area as of June 2023.
  • Symptoms include brown spots with yellow halos, elongated lesions, and ultimately, wilting and drying of leaves, particularly in high humidity conditions.
  • Four similar fungal isolates were identified and characterized morphologically, resembling the Colletotrichum gloeosporioides species complex, with genetic sequences deposited in GenBank for further study.
View Article and Find Full Text PDF
Article Synopsis
  • In summer 2023, a significant outbreak (80% infection rate) of brown necrotic spots was found on two-year-old "Sauvignon Blanc" grapevines in Susegana, Northern Italy, affecting both grafted and ungrafted plants.
  • Leaf samples were sterilized and analyzed in a lab where a fungal isolate was identified, displaying characteristics typical of the Alternaria genus under microscopic examination.
  • Fungal DNA was extracted and specific gene sequences (ITS, ATPase, GAPDH, CAL) were amplified and sent for genomic sequencing, with results stored in GenBank for further research.
View Article and Find Full Text PDF

Causing Anthracnose in in Guangxi, China.

Plant Dis

July 2024

Guangxi Academy of Agricultural Sciences, Institute of Plant Protection, 174 daxue road, Nanning, Guangxi Province, Nanning, Guangxi, China, 530007;

(L.)Jongkind, distributed in Southeast Asia, is widely planted in southern China for its ornamental and medicinal value. In February 2023, anthracnose symptoms were observed on leaves in Nanning Garden Expo (N22°43', E108°28'), Guangxi, China, causing severe defoliation of infected plants with a foliar disease incidence ranging from 40 to 60% (n = 100) in a 2 ha field.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!