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Re-energizing health literacy in Wales: a testbed for health, education and prosperity for all.
Health Promot Int
June 2024
Department of Education and Childhood Studies, Singleton Park Campus, Swansea University, SA2 8PP, UK.
A growing body of evidence demonstrates the importance of enhancing health literacy for improved health outcomes, self-reported health, lower health services use and disease prevention. Importantly, improving health literacy has great potential to reduce health inequities and inequalities. The World Health Organization (WHO) has identified health literacy as a global priority, viewing it as a right and a fundamental competency necessary to function within modern society.
View Article and Find Full Text PDFClinical Translation: Targeting the Estrogen Receptor.
Adv Exp Med Biol
September 2022
Early Clinical Development, Genentech, South San Francisco, CA, USA.
Estrogen Receptor alpha (ERα) stands as one of the most successfully prosecuted drug targets in oncology, beginning with the approval of tamoxifen for women with ERα positive (ER+) breast cancer over 40 years ago. The field continued to advance with the development of aromatase inhibitors and the pure antiestrogen fulvestrant. With multiple endocrine therapies approved for the treatment of ER+ breast cancer, efforts to generate novel ERα-targeted therapeutics somewhat diminished in the early 2000s.
View Article and Find Full Text PDFBioenergetic Failure Drives Functional Exhaustion of Monocytes in Acute-on-Chronic Liver Failure.
Front Immunol
June 2022
Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.
Article Synopsis
- ACLF Monocyte Dysfunction
- : In patients with acute-on-chronic liver failure (ACLF), monocytes exhibit significant functional defects, including impaired phagocytosis and oxidative burst capacity, which are linked to high mortality rates.
- Role of Umbilical Cord Mesenchymal Stem Cells (ucMSCs)
- : Infusing ucMSCs into an ACLF mouse model improved monocyte function, energy levels, and reduced liver injury, suggesting a potential therapeutic avenue.
- Bioenergetic Analysis
- : ACLF monocytes showed decreased oxidative phosphorylation and glycolysis, indicating a severe reduction in energy metabolism that correlates with higher mortality risk in patients.
Looking Back, Looking Forward at Halogen Bonding in Drug Discovery.
Molecules
August 2017
Department of Chemistry, The University of Texas at El Paso, El Paso, TX 79968, USA.
Halogen bonding has emerged at the forefront of advances in improving ligand: receptor interactions. In particular the newfound ability of this extant non-covalent-bonding phenomena has revolutionized computational approaches to drug discovery while simultaneously reenergizing synthetic approaches to the field. Here we survey, via examples of classical applications involving halogen atoms in pharmaceutical compounds and their biological hosts, the unique advantages that halogen atoms offer as both Lewis acids and Lewis bases.
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