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Modular Synthesis of Arylacetic Acid Esters, Thioesters, and Amides from Aryl Ethers via Rh(II)-Catalyzed Diazo Arylation. | LitMetric
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Modular Synthesis of Arylacetic Acid Esters, Thioesters, and Amides from Aryl Ethers via Rh(II)-Catalyzed Diazo Arylation.

Daniel Best Mickaël Jean Pierre van de Weghe

J Org Chem

Université de Rennes 1, UMR CNRS 6226, Institut des Sciences Chimiques de Rennes, Equipe PNSCM, UFR des Sciences, Biologiques et Pharmaceutiques, 2 Avenue du Prof Leon Bernard, Rennes F-35043 Cedex, France.

Published: September 2016

One-pot formation of arylacetic acid esters, thioesters, and amides via Rh(II)-catalyzed arylation of a Meldrum's acid-derived diazo reagent with electron-rich arenes is described. The methodology was used to efficiently synthesize an anticancer compound.

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 Source
http://dx.doi.org/10.1021/acs.joc.6b01426DOI Listing

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